ID   GLPK5_CHICK             Reviewed;         517 AA.
AC   Q5ZMJ4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative glycerol kinase 5;
DE            Short=GK 5;
DE            Short=Glycerokinase 5;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase 5;
GN   Name=GK5; ORFNames=RCJMB04_1n17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC         Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC         EC=2.7.1.30;
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC       pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR   EMBL; AJ719390; CAG31049.1; -; mRNA.
DR   RefSeq; NP_001026477.1; NM_001031306.1.
DR   AlphaFoldDB; Q5ZMJ4; -.
DR   SMR; Q5ZMJ4; -.
DR   STRING; 9031.ENSGALP00000004298; -.
DR   PaxDb; Q5ZMJ4; -.
DR   Ensembl; ENSGALT00000080849; ENSGALP00000048645; ENSGALG00000002729.
DR   GeneID; 424779; -.
DR   KEGG; gga:424779; -.
DR   CTD; 256356; -.
DR   VEuPathDB; HostDB:geneid_424779; -.
DR   eggNOG; KOG2517; Eukaryota.
DR   GeneTree; ENSGT01000000214434; -.
DR   HOGENOM; CLU_009281_2_3_1; -.
DR   InParanoid; Q5ZMJ4; -.
DR   OMA; CTFLTWN; -.
DR   OrthoDB; 519426at2759; -.
DR   PhylomeDB; Q5ZMJ4; -.
DR   TreeFam; TF321504; -.
DR   UniPathway; UPA00618; UER00672.
DR   PRO; PR:Q5ZMJ4; -.
DR   Proteomes; UP000000539; Chromosome 9.
DR   Bgee; ENSGALG00000002729; Expressed in spermatid and 12 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR   GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   CDD; cd07793; FGGY_GK5_metazoa; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR037444; GK5_FGGY.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycerol metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..517
FT                   /note="Putative glycerol kinase 5"
FT                   /id="PRO_0000323756"
FT   BINDING         23
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         270
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         292
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         431..436
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   517 AA;  57261 MW;  3E88E5495BE38EFD CRC64;
     MPCGQPGSGA APALYVVGVD VGSTTVKCHV YDRAAGVRGS SCRKVESLYP RPGWVELDPE
     VLWSQFVGVI KEAVQAAGLH MRQVAALGIS TQRSTFITWH KRTGKPFHNF ISWQDLRSAE
     LVNSWNRSLL LKVIHVIFTV LHFFTGNDRY LAPSVLTFST QQTSMKLSWV FKNIPEADEA
     AKKNNCCFGT VDTWLLYRLT KGSVFATDYS NASSTGVFEP FTKCWNPTLC HLLSIPMSIY
     PPVKDTSFNF GSADSEIFGV PVPIMALVAD QQSAMFGECC FQPGDVKLTM GTGGFWNVNT
     GGNLFASHKG LYPLIGWKIG EEVVYLTEGS MSNIGTTIKW AQDINLFTNV DETAKMARSI
     VDSQGVCFVP GFQVSANDPY LCASFMGLKP TTTRNHLVRA ILESVAFRNK QLFDIIVKKV
     RIPLQTVRAD GGVSNNSFVM QMTSDLINKK IEKPSNTDMS SLGAAFLAGL ASGLWTDKEQ
     LKKLRQIETV FEPQKDEKEY KPAMDTWMRA VKCSLHW