ID   GLPK5_DANRE             Reviewed;         510 AA.
AC   A0JPE9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Putative glycerol kinase 5;
DE            Short=GK 5;
DE            Short=Glycerokinase 5;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase 5;
GN   Name=gk5; ORFNames=zgc:152983;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC         Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC         EC=2.7.1.30;
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC       pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC127390; AAI27391.1; -; mRNA.
DR   AlphaFoldDB; A0JPE9; -.
DR   SMR; A0JPE9; -.
DR   STRING; 7955.ENSDARP00000085784; -.
DR   PaxDb; A0JPE9; -.
DR   ZFIN; ZDB-GENE-061110-49; gk5.
DR   eggNOG; KOG2517; Eukaryota.
DR   InParanoid; A0JPE9; -.
DR   PhylomeDB; A0JPE9; -.
DR   UniPathway; UPA00618; UER00672.
DR   PRO; PR:A0JPE9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR   GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   CDD; cd07793; FGGY_GK5_metazoa; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR037444; GK5_FGGY.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycerol metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..510
FT                   /note="Putative glycerol kinase 5"
FT                   /id="PRO_0000323757"
FT   BINDING         3
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         73
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         250
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         272
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         414..419
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   510 AA;  56486 MW;  650AB68D03349B87 CRC64;
     MGTTSIRCHV YDKSASIRGS CSAKVSLLYP QPGWVEIDPD ELWDGFVTVV KGAVQDSGLQ
     MCQMESLGIS TQRATFMTWD RNTGKPFHKF ITWQDMRAAE LVRSWNGSCA MKTVHGVMKM
     LHFLSRQKRF LAASLVVFTT QHVSLRLVWA LNNIPQLRQA VEDGSCYFGT IDTWLLYKLT
     KGLVHATDYS NASATAIFDS YQMCWSGFLC SLLSIPLSIL PKVQDTSHKF GLCDSSIFGV
     PIPIMCVMAD QQTAMFGECC FDTGDVKITM GTGTFMDINT GSKPHTSVAG LYPLVGWKIG
     ADVVYLAEGN AAGTGAAIKW AQDLELFSDV KETEAIATSV EDSDGVFFVP SFSGLQAPLN
     DPKACASFMG LKPSTTKRHL VRAILESIAF RNKQLFDVML RETRIPITKI RADGGVCTND
     FIMQLTADLL GRKIARPSHF DMSCLGAAFV AGLGTGYWRN QEELKKLLST DQHFLPRRSK
     SEGEKGGLYR GVLQSWEKAL QRSMHWYNQP