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GLPK5_HUMAN
ID   GLPK5_HUMAN             Reviewed;         529 AA.
AC   Q6ZS86; B2R9I2; D3DNG2; Q8N2A7; Q8N5E6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Putative glycerol kinase 5;
DE            Short=GK 5;
DE            Short=Glycerokinase 5;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase 5;
GN   Name=GK5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Amygdala, Kidney, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC         Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC         EC=2.7.1.30;
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC       pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6ZS86-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZS86-2; Sequence=VSP_032122, VSP_032123;
CC       Name=3;
CC         IsoId=Q6ZS86-3; Sequence=VSP_032121;
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR   EMBL; AK090901; BAC03542.1; -; mRNA.
DR   EMBL; AK127641; BAC87068.1; -; mRNA.
DR   EMBL; AK313792; BAG36529.1; -; mRNA.
DR   EMBL; AC108679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW78974.1; -; Genomic_DNA.
DR   EMBL; CH471052; EAW78975.1; -; Genomic_DNA.
DR   EMBL; BC032470; AAH32470.1; -; mRNA.
DR   CCDS; CCDS33871.1; -. [Q6ZS86-1]
DR   RefSeq; NP_001034636.1; NM_001039547.2. [Q6ZS86-1]
DR   AlphaFoldDB; Q6ZS86; -.
DR   SMR; Q6ZS86; -.
DR   BioGRID; 129160; 3.
DR   STRING; 9606.ENSP00000418001; -.
DR   iPTMnet; Q6ZS86; -.
DR   PhosphoSitePlus; Q6ZS86; -.
DR   BioMuta; GK5; -.
DR   DMDM; 338817880; -.
DR   EPD; Q6ZS86; -.
DR   jPOST; Q6ZS86; -.
DR   MassIVE; Q6ZS86; -.
DR   MaxQB; Q6ZS86; -.
DR   PaxDb; Q6ZS86; -.
DR   PeptideAtlas; Q6ZS86; -.
DR   PRIDE; Q6ZS86; -.
DR   ProteomicsDB; 68203; -. [Q6ZS86-1]
DR   ProteomicsDB; 68204; -. [Q6ZS86-2]
DR   ProteomicsDB; 68205; -. [Q6ZS86-3]
DR   Antibodypedia; 35071; 200 antibodies from 26 providers.
DR   DNASU; 256356; -.
DR   Ensembl; ENST00000392993.7; ENSP00000418001.1; ENSG00000175066.16. [Q6ZS86-1]
DR   Ensembl; ENST00000480757.5; ENSP00000419031.1; ENSG00000175066.16. [Q6ZS86-2]
DR   Ensembl; ENST00000492097.5; ENSP00000420312.1; ENSG00000175066.16. [Q6ZS86-2]
DR   GeneID; 256356; -.
DR   KEGG; hsa:256356; -.
DR   MANE-Select; ENST00000392993.7; ENSP00000418001.1; NM_001039547.3; NP_001034636.1.
DR   UCSC; uc003euq.2; human. [Q6ZS86-1]
DR   CTD; 256356; -.
DR   DisGeNET; 256356; -.
DR   GeneCards; GK5; -.
DR   HGNC; HGNC:28635; GK5.
DR   HPA; ENSG00000175066; Low tissue specificity.
DR   neXtProt; NX_Q6ZS86; -.
DR   OpenTargets; ENSG00000175066; -.
DR   PharmGKB; PA162389723; -.
DR   VEuPathDB; HostDB:ENSG00000175066; -.
DR   eggNOG; KOG2517; Eukaryota.
DR   GeneTree; ENSGT01000000214434; -.
DR   HOGENOM; CLU_009281_2_3_1; -.
DR   InParanoid; Q6ZS86; -.
DR   OMA; CTFLTWN; -.
DR   OrthoDB; 519426at2759; -.
DR   PhylomeDB; Q6ZS86; -.
DR   TreeFam; TF321504; -.
DR   BRENDA; 2.7.1.30; 2681.
DR   PathwayCommons; Q6ZS86; -.
DR   UniPathway; UPA00618; UER00672.
DR   BioGRID-ORCS; 256356; 9 hits in 1080 CRISPR screens.
DR   ChiTaRS; GK5; human.
DR   GenomeRNAi; 256356; -.
DR   Pharos; Q6ZS86; Tbio.
DR   PRO; PR:Q6ZS86; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6ZS86; protein.
DR   Bgee; ENSG00000175066; Expressed in ascending aorta and 163 other tissues.
DR   ExpressionAtlas; Q6ZS86; baseline and differential.
DR   Genevisible; Q6ZS86; HS.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR   GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   CDD; cd07793; FGGY_GK5_metazoa; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR037444; GK5_FGGY.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Glycerol metabolism; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..529
FT                   /note="Putative glycerol kinase 5"
FT                   /id="PRO_0000323754"
FT   BINDING         28
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         98
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         275
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         297
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         439..444
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..279
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_032121"
FT   VAR_SEQ         273..301
FT                   /note="VADQQSAMFGECCFQTGDVKLTMGTGTFL -> LKVPGYDQNICYIFGKGTI
FT                   EPVFYHGSTL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032122"
FT   VAR_SEQ         302..529
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032123"
FT   CONFLICT        339
FT                   /note="T -> I (in Ref. 1; BAC87068)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   529 AA;  59156 MW;  9ED7CB1DA4D9417D CRC64;
     MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV ENLYPQIGWV
     EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT FITWNKKTGN HFHNFISWQD
     LRAVELVKSW NNSLLMKIFH SSCRVLHFFT RSKRLFTASL FTFTTQQTSL RLVWILQNLT
     EVQKAVEEEN CCFGTIDTWL LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI
     PLSLLPPVRD TSHNFGSVDE EIFGVPIPIV ALVADQQSAM FGECCFQTGD VKLTMGTGTF
     LDINTGNSLQ QTTGGFYPLI GWKIGQEVVC LAESNAGDTG TAIKWAQQLD LFTDAAETEK
     MAKSLEDSEG VCFVPSFSGL QAPLNDPWAC ASFMGLKPST SKYHLVRAIL ESIAFRNKQL
     YEMMKKEIHI PVRKIRADGG VCKNGFVMQM TSDLINENID RPADIDMSCL GAASLAGLAV
     GFWTDKEELK KLRQSEVVFK PQKKCQEYEM SLENWAKAVK RSMNWYNKT
 
 
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