ID   GLPK5_XENLA             Reviewed;         479 AA.
AC   Q6GP95;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Putative glycerol kinase 5;
DE            Short=GK 5;
DE            Short=Glycerokinase 5;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase 5;
GN   Name=gk5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC         Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC         EC=2.7.1.30;
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC       pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR   EMBL; BC073246; AAH73246.1; -; mRNA.
DR   RefSeq; NP_001085720.1; NM_001092251.1.
DR   AlphaFoldDB; Q6GP95; -.
DR   SMR; Q6GP95; -.
DR   DNASU; 444147; -.
DR   GeneID; 444147; -.
DR   KEGG; xla:444147; -.
DR   CTD; 444147; -.
DR   Xenbase; XB-GENE-983232; gk5.L.
DR   UniPathway; UPA00618; UER00672.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 444147; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd07793; FGGY_GK5_metazoa; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR037444; GK5_FGGY.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycerol metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..479
FT                   /note="Putative glycerol kinase 5"
FT                   /id="PRO_0000323758"
FT   BINDING         20
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         90
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         267
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         289
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         431..436
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   479 AA;  52028 MW;  FB94D2F661C287D0 CRC64;
     MSSPRNGYRD RLILAVDVGS SVLRCHLYNQ SGEICGSAED KLKVLYPQAG YVEIDPESLW
     EQFVRVVKEA VADAGIQMSQ VAGLGISTQR GTFITWNKKT GETFHNFISW QDLRAADLVS
     SWNRSLLLKA VHGVCTALHF FTRRKRFLAA SLINFTTQHV SLRLVWVLQN IPQVRQAAEK
     GNCCFGTIDT WLLHKLTKGT VFATDYSNAS GTAVFDPYLM CWSSFLCSLL SIPLSIFPPV
     EDTSHSFGLA DPTIFGAPVP ILALVADQQA AMFGQCCFDV GSVKLTMGTG SFISINTGET
     LHTSIAGLYP LIGWKVGDEV VCLAEGNASD TGTAIKWAEE LNLFTSVADT EAMARSVPDC
     GGIYLVPSFS GLQAPINDPY ACASFMGLKP STSKSHLVRA ILESVAYRNK QLYDTVLRET
     TIPITLIRAD GGVSNNNFIM QMTADLLGQT IDKPKHTDMS SLGAAFLAGM AVYGPLKTS