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AMIA2_MYCTO
ID   AMIA2_MYCTO             Reviewed;         484 AA.
AC   P9WQ98; L0TCA9; O05835; P63490;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Putative amidase AmiA2;
DE            EC=3.5.1.4;
GN   Name=amiA2; OrderedLocusNames=MT2432;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate +
CC         NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=3.5.1.4;
CC   -!- SIMILARITY: Belongs to the amidase family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46726.1; -; Genomic_DNA.
DR   PIR; B70586; B70586.
DR   RefSeq; WP_003412223.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WQ98; -.
DR   SMR; P9WQ98; -.
DR   EnsemblBacteria; AAK46726; AAK46726; MT2432.
DR   GeneID; 45426350; -.
DR   KEGG; mtc:MT2432; -.
DR   PATRIC; fig|83331.31.peg.2620; -.
DR   HOGENOM; CLU_009600_0_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004040; F:amidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043864; F:indoleacetamide hydrolase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.1300.10; -; 1.
DR   InterPro; IPR000120; Amidase.
DR   InterPro; IPR020556; Amidase_CS.
DR   InterPro; IPR023631; Amidase_dom.
DR   InterPro; IPR036928; AS_sf.
DR   PANTHER; PTHR11895; PTHR11895; 1.
DR   Pfam; PF01425; Amidase; 1.
DR   SUPFAM; SSF75304; SSF75304; 1.
DR   PROSITE; PS00571; AMIDASES; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..484
FT                   /note="Putative amidase AmiA2"
FT                   /id="PRO_0000426813"
FT   ACT_SITE        93
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        167
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        191
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   484 AA;  50884 MW;  90D86CCD0C90F02A CRC64;
     MVGASGSDAG AISGSGNQRL PTLTDLLYQL ATRAVTSEEL VRRSLRAIDV SQPTLNAFRV
     VLTESALADA AAADKRRAAG DTAPLLGIPI AVKDDVDVAG VPTAFGTQGY VAPATDDCEV
     VRRLKAAGAV IVGKTNTCEL GQWPFTSGPG FGHTRNPWSR RHTPGGSSGG SAAAVAAGLV
     TAAIGSDGAG SIRIPAAWTH LVGIKPQRGR ISTWPLPEAF NGVTVNGVLA RTVEDAALVL
     DAASGNVEGD RHQPPPVTVS DFVGIAPGPL KIALSTHFPY TGFRAKLHPE ILAATQRVGD
     QLELLGHTVV KGNPDYGLRL SWNFLARSTA GLWEWAERLG DEVTLDRRTV SNLRMGHVLS
     QAILRSARRH EAADQRRVGS IFDIVDVVLA PTTAQPPPMA RAFDRLGSFG TDRAIIAACP
     STWPWNLLGW PSINVPAGFT SDGLPIGVQL MGPANSEGML ISLAAELEAV SGWATKQPQV
     WWTS
 
 
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