ID   GLPM_PSEAE              Reviewed;         109 AA.
AC   P52112;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Membrane protein GlpM;
GN   Name=glpM; OrderedLocusNames=PA3585;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC   STRAIN=CD10;
RX   PubMed=7642508; DOI=10.1128/jb.177.16.4801-4804.1995;
RA   Schweizer H.P., Po C., Bacic M.K.;
RT   "Identification of Pseudomonas aeruginosa glpM, whose gene product is
RT   required for efficient alginate biosynthesis from various carbon sources.";
RL   J. Bacteriol. 177:4801-4804(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Could play a role in alginate biosynthesis. Overexpression
CC       may be lethal.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are pleiotropically defective in alginate
CC       biosynthesis from various carbon sources. {ECO:0000269|PubMed:7642508}.
CC   -!- SIMILARITY: To E.coli YdgC. {ECO:0000305}.
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DR   EMBL; L06231; AAA81585.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06973.1; -; Genomic_DNA.
DR   PIR; C83197; C83197.
DR   RefSeq; NP_252275.1; NC_002516.2.
DR   RefSeq; WP_003119370.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; P52112; -.
DR   STRING; 287.DR97_4354; -.
DR   TCDB; 9.B.72.1.1; the 4 tms glpm (glpm) family.
DR   PaxDb; P52112; -.
DR   EnsemblBacteria; AAG06973; AAG06973; PA3585.
DR   GeneID; 880180; -.
DR   KEGG; pae:PA3585; -.
DR   PATRIC; fig|208964.12.peg.3752; -.
DR   PseudoCAP; PA3585; -.
DR   HOGENOM; CLU_140962_0_0_6; -.
DR   InParanoid; P52112; -.
DR   OMA; YFVYLAT; -.
DR   BioCyc; PAER208964:G1FZ6-3654-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042121; P:alginic acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009707; GlpM/YdgC.
DR   Pfam; PF06942; GlpM; 1.
PE   4: Predicted;
KW   Alginate biosynthesis; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..109
FT                   /note="Membrane protein GlpM"
FT                   /id="PRO_0000087517"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   109 AA;  12041 MW;  986300E7277AB2A6 CRC64;
     MFKALIGAAV VVLLAVLSKT RNYYIAGLVP LFPTFALIAH YIVGKGRSLD DLKTTIVFGM
     WSIIPYFVYL AALYLLVERF RLETSLALAA LAWLVAASVL VGLWVRLHA