ID   GLPR_HALVD              Reviewed;         255 AA.
AC   D4GYE7;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=HTH-type transcriptional regulator GlpR;
GN   Name=glpR; OrderedLocusNames=HVO_1501; ORFNames=C498_11226;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [3]
RP   INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=DS2 / DS70;
RX   PubMed=20935102; DOI=10.1128/jb.00827-10;
RA   Rawls K.S., Yacovone S.K., Maupin-Furlow J.A.;
RT   "GlpR represses fructose and glucose metabolic enzymes at the level of
RT   transcription in the haloarchaeon Haloferax volcanii.";
RL   J. Bacteriol. 192:6251-6260(2010).
CC   -!- FUNCTION: Transcriptional repressor of genes encoding both fructose and
CC       glucose metabolic enzymes such as phosphofructokinase (PFK) or 2-keto-
CC       3-deoxy-D-gluconate kinase (KDGK) during growth on glycerol. Required
CC       for the glycerol-mediated repression of pfkB-specific transcripts, but
CC       not needed for the high-levels of the pfkB-specific transcript present
CC       when cells are grown on fructose. {ECO:0000269|PubMed:20935102}.
CC   -!- INDUCTION: Expression is repressed by glycerol but highly up-regulated
CC       in the presence of fructose or glucose, regardless of glycerol
CC       supplementation. {ECO:0000269|PubMed:20935102}.
CC   -!- DISRUPTION PHENOTYPE: Leads to pfkB-specific transcript up-regulation.
CC       {ECO:0000269|PubMed:20935102}.
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DR   EMBL; CP001956; ADE04103.1; -; Genomic_DNA.
DR   EMBL; AOHU01000090; ELY28261.1; -; Genomic_DNA.
DR   RefSeq; WP_004043434.1; NZ_AOHU01000090.1.
DR   AlphaFoldDB; D4GYE7; -.
DR   SMR; D4GYE7; -.
DR   IntAct; D4GYE7; 5.
DR   STRING; 309800.C498_11226; -.
DR   EnsemblBacteria; ADE04103; ADE04103; HVO_1501.
DR   EnsemblBacteria; ELY28261; ELY28261; C498_11226.
DR   GeneID; 8924590; -.
DR   KEGG; hvo:HVO_1501; -.
DR   PATRIC; fig|309800.29.peg.2139; -.
DR   eggNOG; arCOG03924; Archaea.
DR   HOGENOM; CLU_060699_1_4_2; -.
DR   OMA; STHEPGF; -.
DR   OrthoDB; 64203at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   Proteomes; UP000011532; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; DNA-binding; Fucose metabolism;
KW   Glucose metabolism; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..255
FT                   /note="HTH-type transcriptional regulator GlpR"
FT                   /id="PRO_0000428912"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   255 AA;  27977 MW;  B35C8466B81A24F8 CRC64;
     MLPAERKRRI VELVSDSDGR SVESLSDHLG YSKATIRRDL RELEDRGLIE RSHGGAVPVT
     SVGREQTYGQ KEVQNLEGKR AIADRAVEEL AEGQVVFFDA GTTTMEVARK VPKDGTILGV
     TNSPRLAIEL NEEDNEVKLT GGTLRRRTKA LVGPTAESFM ERTNFDLLFL GTNALDVESG
     LTTPNEDEAR MKELMVEKAA KVVLVADLSK LGRRSFVQFA SLEEIDLFIT DGTLDADSRE
     EIESAGVTVV DGVAR