GLPT_HAEIN
ID GLPT_HAEIN Reviewed; 480 AA.
AC P96335;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Glycerol-3-phosphate transporter;
DE Short=G-3-P transporter;
DE AltName: Full=G-3-P permease;
GN Name=glpT; OrderedLocusNames=HI_0686;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP SEQUENCE REVISION.
RA White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D., Peterson J.,
RA Hickey E., Dodson R., Gwinn M.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Eagan / Serotype B;
RX PubMed=9714837; DOI=10.1016/s0378-1119(98)00259-5;
RA Song X.M., Forsgren A., Janson H.;
RT "Glycerol-3-phosphate transport in Haemophilus influenzae: cloning,
RT sequencing, and transcription analysis of the glpT gene.";
RL Gene 215:381-388(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NTHi 772;
RA Song X.M., Janson H.;
RT "Different organization and regulation of the glpTQ operons between type b
RT and nontypeable Haemophilus influenzae.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for glycerol-3-phosphate uptake. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22346.1; -; Genomic_DNA.
DR EMBL; AF001172; AAC35741.1; -; Genomic_DNA.
DR EMBL; AF132901; AAD38343.1; -; Genomic_DNA.
DR RefSeq; NP_438846.1; NC_000907.1.
DR RefSeq; WP_005650782.1; NC_000907.1.
DR AlphaFoldDB; P96335; -.
DR SMR; P96335; -.
DR STRING; 71421.HI_0686; -.
DR PRIDE; P96335; -.
DR EnsemblBacteria; AAC22346; AAC22346; HI_0686.
DR KEGG; hin:HI_0686; -.
DR PATRIC; fig|71421.8.peg.717; -.
DR eggNOG; COG2271; Bacteria.
DR HOGENOM; CLU_001265_31_0_6; -.
DR OMA; AMPYLID; -.
DR PhylomeDB; P96335; -.
DR BioCyc; HINF71421:G1GJ1-721-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; IBA:GO_Central.
DR GO; GO:0015169; F:glycerol-3-phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015760; P:glucose-6-phosphate transport; IBA:GO_Central.
DR GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR005267; G3P_transporter.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR021159; Sugar-P_transporter_CS.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00712; glpT; 1.
DR PROSITE; PS00942; GLPT; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Glycerol metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..480
FT /note="Glycerol-3-phosphate transporter"
FT /id="PRO_0000199879"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 58..64
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 86..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 95..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 114..121
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 122..142
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 143..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 162..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..201
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 202..219
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 220..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 296..300
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 301..321
FT /note="Helical; Name=8"
FT /evidence="ECO:0000250"
FT TOPO_DOM 322..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 335..354
FT /note="Helical; Name=9"
FT /evidence="ECO:0000250"
FT TOPO_DOM 355..359
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 360..396
FT /note="Helical; Name=10"
FT /evidence="ECO:0000250"
FT TOPO_DOM 397..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 416..437
FT /note="Helical; Name=11"
FT /evidence="ECO:0000250"
FT TOPO_DOM 438..442
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 443..463
FT /note="Helical; Name=12"
FT /evidence="ECO:0000250"
FT TOPO_DOM 464..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 480 AA; 53045 MW; 6773C2E8013CB027 CRC64;
MFGPFKPAPH IAELPAEKID STYKRLRWQV FAGIFFGYAA YYFVRANFDL AQPGLIQAGL
YSKAELGVIG SAAGLAYGLS KFVMAGMSDR SNPRVFLPFG LLLSGLCMTL MGLFPWATSG
IAIMWVMIFL NGWFQGMGWP PCGRTMVHWW SKSERGTIVS IWNTAHNIGG MVPGAMVLLA
SAIFFSTHGI EAQAKDVWQQ SLYFPGIAAM IFAIPVYFVM RDTPQSCGLP SIEKWRNDYP
DDYNEKTYEN DLTAKEIFVT YVLKNKLLWY IAIANVFVYL IRYGVLKWSP VYLSEVKHFN
IKGTAWAYTI YELAAVPGTL LCGWVSDKVF KGKRGLTGFI FMILTTAAVV AYWMNPATPE
AELANYSAWY ENPYQLTDFV LMTLIGFLIY GPVMLIGLHA LELAPKKAAG TAAGFTGLFG
YLGGTVSASA VIGWAAQHYG WDGGFYVMIG GGVLAVLLLL IVMVEEGKHK AKLGDTYGTK
