GLR13_ARATH
ID GLR13_ARATH Reviewed; 860 AA.
AC Q9FH75;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Glutamate receptor 1.3;
DE AltName: Full=Ligand-gated ion channel 1.3;
DE Flags: Precursor;
GN Name=GLR1.3; OrderedLocusNames=At5g48410; ORFNames=MJE7.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. May be involved in light-signal transduction and
CC calcium homeostasis via the regulation of calcium influx into cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in roots.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
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DR EMBL; AB020745; BAA96961.2; -; Genomic_DNA.
DR EMBL; CP002688; AED95667.1; -; Genomic_DNA.
DR EMBL; AY091121; AAM14071.1; -; mRNA.
DR EMBL; AY142599; AAN13168.1; -; mRNA.
DR RefSeq; NP_199652.1; NM_124216.3.
DR AlphaFoldDB; Q9FH75; -.
DR SMR; Q9FH75; -.
DR BioGRID; 20142; 14.
DR IntAct; Q9FH75; 5.
DR STRING; 3702.AT5G48410.1; -.
DR PaxDb; Q9FH75; -.
DR PRIDE; Q9FH75; -.
DR EnsemblPlants; AT5G48410.1; AT5G48410.1; AT5G48410.
DR GeneID; 834896; -.
DR Gramene; AT5G48410.1; AT5G48410.1; AT5G48410.
DR KEGG; ath:AT5G48410; -.
DR Araport; AT5G48410; -.
DR TAIR; locus:2166006; AT5G48410.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_0_1; -.
DR InParanoid; Q9FH75; -.
DR OMA; VNQFEWS; -.
DR OrthoDB; 188544at2759; -.
DR PhylomeDB; Q9FH75; -.
DR PRO; PR:Q9FH75; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FH75; baseline and differential.
DR Genevisible; Q9FH75; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR001320; Iontro_rcpt.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..860
FT /note="Glutamate receptor 1.3"
FT /id="PRO_0000011594"
FT TOPO_DOM 28..557
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 579..587
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 588..608
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 609..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..789
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 790..810
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 811..860
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 493
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 523
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 745
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 860 AA; 97024 MW; 47AFFE5C9D9EB62A CRC64;
MERFCIQTQT LLSFLLVLLL FISRSFASTK NDDVDGGKRV QIRVGLVLDL GSLKGKIVKN
SVSMALSYFY AIHNDYKTRV SVSLRNSHGE PLLALASAVD LLKTEGVEAI IGGNSLLEAK
LLGELGEKAR VPMISLDSPF SLSLSKYTHL IQATHDSTSE AKGITSFINV FDWNSVALVY
EDHDDWRESM QLLVEHFHEN GVRVQSKVGF TVSSSEDFVM GRLQQLKDLG TTVFVVHLSE
VIATHLFPCA RRLGLMGDGF VWILTAKTMN SFHENIDDFT KQAMEGVVGF KSYIPMSIEL
QNFTLRWRKS LPVEEAELTR LSISGIWAHD IAFALARAAE VIRMPNVTST LLEEITKTRF
NGLSGDFQLN DKKLLSNKFE IINMIGSSER RVGFLNSNGS FSNRRHLSST HNKLETIIWP
GGSAQSPKGT SLIDSDRKKL RVLVTSSNRF PRLMKVETDP VTNELIVEGF CIEVFRASIS
PFNYEVEYIP WLNGSNYDNL AYALHSQKDK YDAAVGDITI TSNRSTYVDF TLPFTEMGLG
IVAVKERSMW VFFQPLTPDL WITSAFFFVL TGVIVWLIER AENKEFQGSW PQQIGVVLWF
GFSTLVYAHR EKLKHNLSRF VVTVWVFAVL ILTASYTATL TSMMTVQQIR FNSNEDYVGH
LSGSLIANVA LTSSSLRAMR SLGLNSAADY AQALLNKTVS FVVDELPYLK VVLGENPTHF
FMVKTQSTTN GFGFMFQKGF ELVPNVSREI SKLRTSEKLN EMEKRWFDNQ LPYTTDDTSN
PITLYRFRGL FIIIGVSFAF ALAVLVILCL RDKWEILVDN LDLSQRLRHF RIHFVRSIHT
SPLDDPIGET AVQMAQQNRQ
