GLR22_ARATH
ID GLR22_ARATH Reviewed; 920 AA.
AC Q9SHV1;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Glutamate receptor 2.2;
DE AltName: Full=Ligand-gated ion channel 2.2;
DE Flags: Precursor;
GN Name=GLR2.2; OrderedLocusNames=At2g24720; ORFNames=F27A10.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. May be involved in light-signal transduction and
CC calcium homeostasis via the regulation of calcium influx into cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in roots.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
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DR EMBL; AY072068; AAL61997.1; -; mRNA.
DR EMBL; AC007266; AAD26895.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07622.1; -; Genomic_DNA.
DR PIR; B84640; B84640.
DR RefSeq; NP_180048.1; NM_128033.2.
DR AlphaFoldDB; Q9SHV1; -.
DR SMR; Q9SHV1; -.
DR BioGRID; 2360; 7.
DR IntAct; Q9SHV1; 1.
DR STRING; 3702.AT2G24720.1; -.
DR PaxDb; Q9SHV1; -.
DR PRIDE; Q9SHV1; -.
DR ProteomicsDB; 247399; -.
DR EnsemblPlants; AT2G24720.1; AT2G24720.1; AT2G24720.
DR GeneID; 817008; -.
DR Gramene; AT2G24720.1; AT2G24720.1; AT2G24720.
DR KEGG; ath:AT2G24720; -.
DR Araport; AT2G24720; -.
DR TAIR; locus:2047256; AT2G24720.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_2_1; -.
DR InParanoid; Q9SHV1; -.
DR OMA; LEIYDIA; -.
DR OrthoDB; 188544at2759; -.
DR PhylomeDB; Q9SHV1; -.
DR PRO; PR:Q9SHV1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SHV1; baseline and differential.
DR Genevisible; Q9SHV1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR001320; Iontro_rcpt.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..920
FT /note="Glutamate receptor 2.2"
FT /id="PRO_0000011597"
FT TOPO_DOM 25..580
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 602..610
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 632..635
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 657..830
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 852..920
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 477
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 702
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 920 AA; 102847 MW; A08EBFE13EAC2EAB CRC64;
MKNSKLFFRF LFLFFFFCLE SSRGQDNGKT QVNIGVVSDV GTSYPDVAML CINMSLADFY
SSRPQFQTRL VVNVGDSKND VVGAATAAID LIKNKQVKAI LGPWTSMQAH FLIEIGQKSR
VPVVSYSATS PSLTSLRSPY FFRATYEDSS QVHAIKAIIK LFGWREVVPV YIDNTFGEGI
MPRLTDSLQD INVRIPYRSV IPLNATDQDI SVELLKMMNM PTRVFIVHMS SSLASTVFIK
AKELGLMKPG YVWILTNGVM DGLRSINETG IEAMEGVLGI KTYIPKSKDL ETFRSRWKRR
FPQMELNVYG LWAYDATTAL AMAIEDAGIN NMTFSNVDTG KNVSELDGLG LSQFGPKLLQ
TVSTVQFKGL AGDFHFVSGQ LQPSVFEIVN MIGTGERSIG FWTEGNGLVK KLDQEPRSIG
TLSTWPDHLK HIIWPGEAVS VPKGWEIPTN GKKLRIGVPK RIGFTDLVKV TRDPITNSTV
VKGFCIDFFE AVIQAMPYDV SYEFFPFEKP NGEPAGNHND LVHQVYLGQF DAVVGDTTIL
ANRSSFVDFT LPFMKSGVGL IVPLKDEVKR DKFSFLKPLS IELWLTTLVF FFLVGISVWT
LEHRVNSDFR GPANYQASTI FWFAFSTMVF APRERVLSFG ARSLVVTWYF VLLVLTQSYT
ASLASLLTSQ QLNPTITSMS SLLHRGETVG YQRTSFILGK LNETGFPQSS LVPFDTAEEC
DELLKKGPKN GGVAAAFLGT PYVRLFLGQY CNTYKMVEEP FNVDGFGFVF PIGSPLVADV
SRAILKVAES PKAVELEHAW FKKKEQSCPD PVTNPDSNPT VTAIQLGVGS FWFLFLVVFV
VCVLALGKFT FCFLWKTKGK DLWKEFLKRD TDSYINDIEK CLCSQEMPEN SNKATNQTNY
GMELRVRNIV QVNQTDPDCL
