GLR27_ARATH
ID GLR27_ARATH Reviewed; 952 AA.
AC Q8LGN0; O81080; Q6RKN3; Q8RY02;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 3.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Glutamate receptor 2.7;
DE AltName: Full=Ligand-gated ion channel 2.7;
DE Flags: Precursor;
GN Name=GLR2.7; OrderedLocusNames=At2g29120; ORFNames=T9I4.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 27-952, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 560-952.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. May be involved in light-signal transduction and
CC calcium homeostasis via the regulation of calcium influx into cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in leaves.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC33239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY495450; AAR88101.1; -; mRNA.
DR EMBL; AC005315; AAC33239.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08213.1; -; Genomic_DNA.
DR EMBL; AY072069; AAL61998.1; -; mRNA.
DR EMBL; AY080587; AAL85964.2; -; mRNA.
DR PIR; T02742; T02742.
DR RefSeq; NP_180476.3; NM_128469.4.
DR AlphaFoldDB; Q8LGN0; -.
DR SMR; Q8LGN0; -.
DR BioGRID; 2810; 9.
DR STRING; 3702.AT2G29120.1; -.
DR PaxDb; Q8LGN0; -.
DR PRIDE; Q8LGN0; -.
DR ProteomicsDB; 247363; -.
DR EnsemblPlants; AT2G29120.1; AT2G29120.1; AT2G29120.
DR GeneID; 817460; -.
DR Gramene; AT2G29120.1; AT2G29120.1; AT2G29120.
DR KEGG; ath:AT2G29120; -.
DR Araport; AT2G29120; -.
DR TAIR; locus:2066107; AT2G29120.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_2_1; -.
DR InParanoid; Q8LGN0; -.
DR OMA; HPINEDF; -.
DR OrthoDB; 188544at2759; -.
DR PhylomeDB; Q8LGN0; -.
DR PRO; PR:Q8LGN0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8LGN0; baseline and differential.
DR Genevisible; Q8LGN0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR001320; Iontro_rcpt.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..952
FT /note="Glutamate receptor 2.7"
FT /id="PRO_0000011602"
FT TOPO_DOM 33..582
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 604..612
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 613..633
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 634..637
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 659..821
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 822..842
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 843..952
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 889..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 664
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 728
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 748
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 784
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 809
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 952 AA; 107406 MW; C3B17031880DD48C CRC64;
MKVMNPRKTN NTFMYYFVLF VCGFVLMEGC LGQNQTTEIK VGVVLDLHTS FSKLCLTSIN
ISLSDFYKYH SDYTTRLAIH IRDSMEDVVQ ASSAALDLIK NEQVSAIIGP RTSMQAEFMI
RLADKSQVPT ITFSATCPLL TSINSPYFVR ATLDDSSQVK AIAAIVKSFG WRNVVAIYVD
NEFGEGILPL LTDALQDVQA FVVNRCLIPQ EANDDQILKE LYKLMTMQTR VFVVHMPPTL
GFRFFQKARE IGMMEEGYVW LLTDGVMNLL KSNERGSSLE NMQGVLGVRS HIPKSKKLKN
FRLRWEKMFP KKGNDEEMNI FALRAYDSIT ALAMAVEKTN IKSLRYDHPI ASGNNKTNLG
TLGVSRYGPS LLKALSNVRF NGLAGEFELI NGQLESSVFD VINIIGSEER IIGLWRPSNG
IVNAKSKNTT SVLGERLGPV IWPGKSKDVP KGWQIPTNGK MLRVGIPVKK GFLEFVDAKI
DPISNAMTPT GYCIEIFEAV LKKLPYSVIP KYIAFLSPDE NYDEMVYQVY TGAYDAVVGD
VTIVANRSLY VDFTLPYTES GVSMMVPLKD NKNTWVFLRP WSLDLWVTTA CFFVFIGFIV
WILEHRVNTD FRGPPHHQIG TSFWFAFSTM NFAHREKVVS NLARFVVLVW CFVVLVLIQS
YTANLTSFFT VKLLQPTVTN WKDLIKFNKN IGYQRGTFVR ELLKSQGFDE SQLKPFGSAV
ECDELFSNGT ITASFDEVAY IKVILSQNSS KYTMVEPSFK TAGFGFVFPK KSPLTDDVSR
AILNVTQGEE MQHIENKWFK KPNNCPDLNT SLSSNHLSLS SFWGLFLIAG IASFLALLIF
VANFLYEHKH TLFDDSENSF RGKLKFLVRN FDEKDIKSHM FKENAVHNVS SPITQGSSSP
LTDQSTPLPR SPEQYRELEL RRVSSISSGE LFTTQSEQVE DEESAIIQCE GE
