GLR28_ARATH
ID GLR28_ARATH Reviewed; 947 AA.
AC Q9C5V5; O81079;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Glutamate receptor 2.8;
DE AltName: Full=Ligand-gated ion channel 2.8;
DE Flags: Precursor;
GN Name=GLR2.8; Synonyms=GLUR9; OrderedLocusNames=At2g29110; ORFNames=T9I4.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. May be involved in light-signal transduction and
CC calcium homeostasis via the regulation of calcium influx into cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in leaves.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC33237.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ311495; CAC29254.1; -; mRNA.
DR EMBL; AC005315; AAC33237.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08212.1; -; Genomic_DNA.
DR PIR; T02741; T02741.
DR RefSeq; NP_180475.2; NM_128468.2.
DR AlphaFoldDB; Q9C5V5; -.
DR SMR; Q9C5V5; -.
DR STRING; 3702.AT2G29110.1; -.
DR PaxDb; Q9C5V5; -.
DR PRIDE; Q9C5V5; -.
DR EnsemblPlants; AT2G29110.1; AT2G29110.1; AT2G29110.
DR GeneID; 817459; -.
DR Gramene; AT2G29110.1; AT2G29110.1; AT2G29110.
DR KEGG; ath:AT2G29110; -.
DR Araport; AT2G29110; -.
DR TAIR; locus:2066086; AT2G29110.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_2_1; -.
DR InParanoid; Q9C5V5; -.
DR OMA; IMIKQPA; -.
DR PhylomeDB; Q9C5V5; -.
DR PRO; PR:Q9C5V5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9C5V5; baseline and differential.
DR Genevisible; Q9C5V5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR001320; Iontro_rcpt.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..947
FT /note="Glutamate receptor 2.8"
FT /id="PRO_0000011603"
FT TOPO_DOM 27..577
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 578..598
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 599..607
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 608..628
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 629..632
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 654..819
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 820..840
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 841..947
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 348
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 524
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 659
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 723
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 779
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 552
FT /note="E -> G (in Ref. 1; CAC29254)"
FT /evidence="ECO:0000305"
FT CONFLICT 700
FT /note="K -> Q (in Ref. 1; CAC29254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 947 AA; 107189 MW; D519F97B813B0BA8 CRC64;
MNPKKNNNTF LSYFVCLFLL LEVGLGQNQI SEIKVGVVLD LNTTFSKICL TSINLALSDF
YKDHPNYRTR LALHVRDSMK DTVQASAAAL DLIQNEQVSA IIGPIDSMQA KFMIKLANKT
QVPTISFSAT SPLLTSIKSD YFVRGTIDDS YQVKAIAAIF ESFGWRSVVA IYVDNELGEG
IMPYLFDALQ DVQVDRSVIP SEANDDQILK ELYKLMTRQT RVFVVHMASR LASRIFEKAT
EIGMMEEGYV WLMTNGMTHM MRHIHHGRSL NTIDGVLGVR SHVPKSKGLE DFRLRWKRNF
KKENPWLRDD LSIFGLWAYD STTALAMAVE KTNISSFPYN NASGSSNNMT DLGTLHVSRY
GPSLLEALSE IRFNGLAGRF NLIDRQLESP KFEIINFVGN EERIVGFWTP SNGLVNVNSN
KTTSFTGERF GPLIWPGKST IVPKGWEIPT NGKKIKVGVP VKKGFFNFVE VITDPITNIT
TPKGYAIDIF EAALKKLPYS VIPQYYRFES PDDDYDDLVY KVDNGTLDAV VGDVTITAYR
SLYADFTLPY TESGVSMMVP VRDNENKNTW VFLKPWGLDL WVTTACFFVL IGFVVWLFEH
RVNTDFRGPP HHQIGTSFWF SFSTMVFAHR EKVVSNLARF VVVVWCFVVL VLTQSYTANL
TSFLTVQRFQ PAAINVKDLI KNGDYVGYQH GAFVKDFLIK EGFNVSKLKP FGSSEECHAL
LSNGSISAAF DEVAYLRAIL SQYCSKYAIV EPTFKTAGFG FAFPRNSPLT GDVSKAILNV
TQGDEMQHIE NKWFMKQNDC PDPKTALSSN RLSLRSFWGL FLIAGIASFL ALLIFVFLFL
YENRHTLCDD SEDSIWRKLT SLFRNFDEKD IKSHTFKSSA VHHVSSPMTQ YIPSPSTLQI
APRPHSPSQD RAFELRRVSF TPNEERLTTQ TIHFEDEESD IECVVEQ
