GLR29_ARATH
ID GLR29_ARATH Reviewed; 940 AA.
AC O81078;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Glutamate receptor 2.9;
DE AltName: Full=Ligand-gated ion channel 2.9;
DE Flags: Precursor;
GN Name=GLR2.9; OrderedLocusNames=At2g29100; ORFNames=T9I4.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. May be involved in light-signal transduction and
CC calcium homeostasis via the regulation of calcium influx into cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in roots.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
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DR EMBL; AC005315; AAC33236.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08211.1; -; Genomic_DNA.
DR PIR; T02740; T02740.
DR RefSeq; NP_180474.1; NM_128467.1.
DR AlphaFoldDB; O81078; -.
DR SMR; O81078; -.
DR BioGRID; 2808; 20.
DR IntAct; O81078; 8.
DR STRING; 3702.AT2G29100.1; -.
DR PaxDb; O81078; -.
DR PRIDE; O81078; -.
DR EnsemblPlants; AT2G29100.1; AT2G29100.1; AT2G29100.
DR GeneID; 817458; -.
DR Gramene; AT2G29100.1; AT2G29100.1; AT2G29100.
DR KEGG; ath:AT2G29100; -.
DR Araport; AT2G29100; -.
DR TAIR; locus:2066148; AT2G29100.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_2_1; -.
DR InParanoid; O81078; -.
DR OMA; WHRTIAT; -.
DR PhylomeDB; O81078; -.
DR PRO; PR:O81078; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O81078; baseline and differential.
DR Genevisible; O81078; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR001320; Iontro_rcpt.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..940
FT /note="Glutamate receptor 2.9"
FT /id="PRO_0000011604"
FT TOPO_DOM 24..566
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..596
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..617
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 618..628
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 650..811
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 812..832
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 833..940
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 876..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 338
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 771
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 776
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 805
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 940 AA; 106266 MW; 4A30095130327A87 CRC64;
MKTNNTFLSY FVCGFLLMGV GLGQNQTSEI KVGVVLDLNT TFSKICLTSI KMAVSDFYAD
HPNYLTRLTL HVRDSMEDTV QASAAALDLI KTEQVSAIIG PINSMQADFM IKLANKTQVP
TITFSATSPL LTSIKSPYFV RATIDDSSQV RAIASIFKFF RWRRVVAIYV DNEFGEGFMP
FLFDALQDVE VKRSVIPPEA IDDEIQKELR KLMERQARVF VVHMESSLAL RVFQIARDIG
MMEEGYVWLM TNGMTHMMRH INNGRSLNTI EGVLGVRSHV PKSKELGDFR LRWKRTFEKE
NPSMRDDLNV FALWAYDSIT ALAKAVEKAN TKSLWYDNGS TLSKNRTDLG NVGVSLYGPS
LQKAFSEVRF NGLAGEFKLI DGQLQSPKFE IINFVGNEER IIGFWTPRDG LMDATSSNKK
TLGPVIWPGK SKIVPKGWEI PGKKLRVGVP MKKGFFDFVK VTINPITNKK TPTGYAIEIF
EAALKELPYL VIPEYVSFES PNNYNNLVYQ VYDKTWDAVV GDITITANRS LYADFTLPFT
ESGVSMMVPV RDNENKDTWV FLEPWSLELW VTTGCFFVFI GFVVWLFEHR VNTDFRGPPQ
YQIGTSLWFS FSTMVFAHRE NVVSNLARFV VVVWCFVVLV LTQSYTASLT SFLTVQSLQP
TVTNVNDLIK NRDCVGYQGG AFVKDILLGL GFHEDQLKPF DSAKDADDLL SKGKSKGIAA
AFDEVAYLKA ILSQSCSKYV MVEPTFKTGG FGFAFPKNSP LTGEFSRAIL NLTQNNVTQQ
IEDRWFPKKN DCPDPMTALS SNRLNLSSFL GLFLIAGTAI SFSLLVFVAL FLYEHRHTLG
DDSEDSLWRK LKFLFKIFDE KDMNSHTFKN SAIHNISSPM THKTPSPSTV QITPWPQSPS
QNREFELRRV SFSPSEERFT TQPIIHHEDG ESDIECRVEQ
