GLRB4_CAEEL
ID GLRB4_CAEEL Reviewed; 473 AA.
AC Q09453;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Glycine receptor subunit beta-type 4;
DE Flags: Precursor;
GN Name=ggr-1; Synonyms=gbr-4; ORFNames=C09G5.1/C09G5.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel
CC opening is triggered by extracellular glycine. Contributes to the
CC generation of inhibitory postsynaptic currents.
CC {ECO:0000250|UniProtKB:P48168}.
CC -!- SUBUNIT: Pentamer. {ECO:0000250|UniProtKB:P48167}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P48167}. Synapse {ECO:0000250|UniProtKB:P48168}.
CC Cell membrane {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:P23415}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Glycine receptor (TC 1.A.9.3) subfamily. {ECO:0000305}.
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DR EMBL; Z46791; CAA86760.2; -; Genomic_DNA.
DR PIR; T19145; T19145.
DR RefSeq; NP_496306.2; NM_063905.3.
DR AlphaFoldDB; Q09453; -.
DR SMR; Q09453; -.
DR STRING; 6239.C09G5.1; -.
DR PaxDb; Q09453; -.
DR PRIDE; Q09453; -.
DR EnsemblMetazoa; C09G5.1.1; C09G5.1.1; WBGene00001586.
DR GeneID; 191636; -.
DR KEGG; cel:CELE_C09G5.1; -.
DR UCSC; C09G5.1; c. elegans.
DR CTD; 191636; -.
DR WormBase; C09G5.1; CE36915; WBGene00001586; ggr-1.
DR eggNOG; KOG3644; Eukaryota.
DR HOGENOM; CLU_010920_0_1_1; -.
DR InParanoid; Q09453; -.
DR OMA; EITHHII; -.
DR OrthoDB; 614790at2759; -.
DR PhylomeDB; Q09453; -.
DR Reactome; R-CEL-112314; Neurotransmitter receptors and postsynaptic signal transmission.
DR PRO; PR:Q09453; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00001586; Expressed in larva and 3 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..473
FT /note="Glycine receptor subunit beta-type 4"
FT /id="PRO_0000000426"
FT TOPO_DOM 20..249
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TRANSMEM 250..271
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TOPO_DOM 272..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TRANSMEM 277..297
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TOPO_DOM 298..308
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TRANSMEM 309..329
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TOPO_DOM 330..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TRANSMEM 440..460
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT TOPO_DOM 461..473
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P23415"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 166..180
FT /evidence="ECO:0000250|UniProtKB:P23415"
SQ SEQUENCE 473 AA; 55540 MW; 0290671D994F7307 CRC64;
MHSLFLKILI YSLMQCVLGQ AEFWDYDENV TQIEEDFKID DVTRILKRVG NYNRNAYPLL
DQDLATHVDI QMYIEGMSSF HAQSMDFQVD IYFQEKWVDH RLQHNNTKRI LVKDPKLFGL
LWHPDLYFAN ARTASFHDVT QPNFLVWIYP NGTVWYDCRI SLTVLCMQDL ARYPLDSQNC
GLRILSYAYD EEQLIIRWNG GNPVEVNRGI RMPDMHLKHI KFYTKRDKYA TGIWSSAVAE
FHVDREITHH IIQSYIPTSL IVIISWFSFW LDVEAVPGRV SLSITTLLTL ATQSSAARMA
LPQASDVKAI DVWMGTCMAF VFSAMIEFTV VNYCVRRKVR TKIKPRGLSE QVHDMVAQYR
EKKDKFNNGN CEISYEMALQ PNEDNATVQR NFEKKEVREM NQASLFVRRS LLPTSKRKTI
EDRINRVEEN RKNAQKIDRY SRALFPLAFI IFNIFYWIYY LKYAGSNSPE LLL
