ID   GLRK_ANAPL              Reviewed;         487 AA.
AC   Q90218;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable glutamate receptor;
DE   AltName: Full=Kainate-binding protein;
DE   Flags: Precursor;
GN   Name=KBP;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8389959; DOI=10.1016/0169-328x(93)90022-h;
RA   Kimura N., Kurosawa N., Kondo K., Tsukada Y.;
RT   "Molecular cloning of the kainate-binding protein and calmodulin genes
RT   which are induced by an imprinting stimulus in ducklings.";
RL   Brain Res. Mol. Brain Res. 17:351-355(1993).
CC   -!- FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system. The
CC       postsynaptic actions of Glu are mediated by a variety of receptors that
CC       are named according to their selective agonists (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Postsynaptic cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000305}.
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DR   EMBL; D83351; BAA11897.1; -; mRNA.
DR   PIR; I51201; I51201.
DR   RefSeq; NP_001297319.1; NM_001310390.1.
DR   RefSeq; XP_005011100.1; XM_005011043.2.
DR   AlphaFoldDB; Q90218; -.
DR   SMR; Q90218; -.
DR   Ensembl; ENSAPLT00020023247; ENSAPLP00020021548; ENSAPLG00020015073.
DR   GeneID; 101799836; -.
DR   KEGG; apla:101799836; -.
DR   CTD; 101799836; -.
DR   HOGENOM; CLU_007257_0_0_1; -.
DR   OMA; DFSHSFY; -.
DR   OrthoDB; 188544at2759; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_rcpt_met.
DR   InterPro; IPR001320; Iontro_rcpt.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..487
FT                   /note="Probable glutamate receptor"
FT                   /id="PRO_0000011556"
FT   TOPO_DOM        24..169
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..419
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        441..487
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  54438 MW;  053F78AA8AFA40BD CRC64;
     MDKGQHFVFF VLTTVLLLRE SSHAGAMRND AAASKDTDLR GPEENLPTLT VTTILEDPYV
     MVRRAELEGY CIDLLKALAS MLHFSYKVKV VGDGKYGAVS SNGNWTGMIG EILRQEADIA
     VAPLTVTSAR EEVVSFTTPF LQTGIGILLR KDTMSQEMSF FHFLAPFSKE TWTGLLFAYI
     LTCFCLFLVA RLSPCEWNEP KNEENHFTFL NSLWFGAGAL ALQGVTPRPK ALSVRVIAAI
     WWLFTIALLA AYIANFTALL SSGSEQLPIQ TFEDLVKQRK LEFGTLDGSS TFYYFKNSKN
     PIHQMIYEYM DKRRDHVLVK TYQEAVQRVM DSNYAFIGES ISQDLAAARH CNLIRAPEVI
     GARGFGIATA QASPWTKKLS IAVLKLRESG DLDYLRNKWW ETSCLHKSRE RWSPLQPQAL
     GGLFLTLAIG LALGVIAAVV ELSNKSRHAA GHVKKSCCSI FTEEMCTRLR IKENTRQSQE
     TSGRANA