ID   GLRK_LITBE              Reviewed;         487 AA.
AC   P20262;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Probable glutamate receptor;
DE   AltName: Full=Kainate-binding protein;
DE            Short=KBP;
DE   Flags: Precursor;
OS   Lithobates berlandieri (Rio Grande leopard frog) (Rana berlandieri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=30360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 150-175.
RC   TISSUE=Brain;
RX   PubMed=2556640; DOI=10.1038/342684a0;
RA   Wada K., Dechesne C.J., Shimasaki S., King R.G., Kusano K., Buonanno A.,
RA   Hampson D.R., Banner C., Wenthold R.J., Nakatani Y.;
RT   "Sequence and expression of a frog brain complementary DNA encoding a
RT   kainate-binding protein.";
RL   Nature 342:684-689(1989).
CC   -!- FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system. The
CC       postsynaptic actions of Glu are mediated by a variety of receptors that
CC       are named according to their selective agonists.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Postsynaptic cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000305}.
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DR   EMBL; X17314; CAA35193.1; -; mRNA.
DR   PIR; S07061; S07061.
DR   AlphaFoldDB; P20262; -.
DR   SMR; P20262; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_rcpt_met.
DR   InterPro; IPR001320; Iontro_rcpt.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Glycoprotein; Ion channel;
KW   Ion transport; Ligand-gated ion channel; Membrane;
KW   Postsynaptic cell membrane; Receptor; Signal; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..487
FT                   /note="Probable glutamate receptor"
FT                   /id="PRO_0000011558"
FT   TOPO_DOM        18..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..413
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        435..487
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          464..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   487 AA;  54278 MW;  442E31E1E7224572 CRC64;
     MEKALMLFLA VSLLSLGHTD GKENAETLLK ERTKRQIPKT LTVTTILEKP FAMKTESDAL
     EGYAIDLLSE LTQSLGFNYT LHIVKDGKYG SKDQEGNWSG MVGEIIRKEA DLAIAPLTIT
     SVRENAISFT KPFMQTGIGI LLKKDTAAES SYMFGFLNPF SKELWIGIII SYVITSLCLF
     LVGRLSPCEW TEPASEQNQF TLLNSLWYGV GALTLQGAEP QPKALSARII AVIWWVFSIT
     LLAAYIGSFA SYINSNTNQT PNIQSVEDLL KQDKLDFGTL SNSSTLNFFK NSKNPTFQMI
     YEYMDKRKDR VLVKTFSEGV QRVRESNYAF LGESISQDFV VAKHCDLIRA PEMIGGRGYG
     IAAELDSPLI RPLTIAILEL FESGKLEYLR QKWWENTCST QDQTGWVPVQ PHTLGGIFLI
     LGIGLALGLI VSFMELMCKS RSNAEQQKKS CCSAFSEEIA QRFGKTQNQE GLEKKSPTSN
     SCDEVKA