ID   GLRK_LYMST              Reviewed;         917 AA.
AC   P26591;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Glutamate receptor;
DE   Flags: Precursor;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1659993; DOI=10.1016/0014-5793(91)80846-u;
RA   Hutton M.L., Harvey R.J., Barnard E.A., Darlison M.G.;
RT   "Cloning of a cDNA that encodes an invertebrate glutamate receptor
RT   subunit.";
RL   FEBS Lett. 292:111-114(1991).
CC   -!- FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system. The
CC       postsynaptic actions of Glu are mediated by a variety of receptors.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Postsynaptic cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000305}.
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DR   EMBL; X60086; CAA42683.1; -; mRNA.
DR   PIR; S18443; ACGAE.
DR   AlphaFoldDB; P26591; -.
DR   SMR; P26591; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_rcpt_met.
DR   InterPro; IPR001320; Iontro_rcpt.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..917
FT                   /note="Glutamate receptor"
FT                   /id="PRO_0000011560"
FT   TOPO_DOM        20..556
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        557..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        578..631
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        632..652
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        653..818
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        819..839
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        840..917
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          871..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        125
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        251
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        272
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        419
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        424
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        491
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        775
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   917 AA;  103139 MW;  4928113CE2CA0527 CRC64;
     MDTCVFPLVV LWISMRITST LDEVPIGGIF DSRSVQALTA FRHEIHMFNR AYSHVYRYKL
     KNDTTILDVT DSFAVSNALC HHLSRGDLAI FGVSNASSLA TIQSYTDTFN VPFVTISMAQ
     NNSHNGSYQI YMRPMYINAL VDVIVHYRWE KVAFYYDSDE GLVRLQQLFQ ATNKYDKMII
     SIDTKRITSV ENGYHMLKEL HLMDPEMEHR VLLDVRTDKA EQIILKVMND SKINNAKFHF
     LLGDLGMLEI NTTHFKIGGV NITGFQLVDP FNSTSELFIS TWSSLDPVYW PGAGTNHVNY
     EAALAADSVR LFKSAFGSIL QKDPNFLRRS RSGTAGKSMK CTDDSEIKTG HGQMILEEMK
     KVKFEGVTGH VAFNEQGHRK DFTLGVYNVA MTRGTAKIGY WNEREGKLHA HNPRLFQNNS
     SDMNRTRIVT TIIKEPYVMV NNVIRDGKPL VGNEPVEGFC IDLTKAVAEK VGFDFVIQFV
     KDGSYGSVLS NGTWDGIVGE LIRHEADMAI APFTITADRS RVIDFTKPFM SLGISIMIKR
     PQPAGKHFFS FMEPLSSEIW MCIVFAYIGV SVVLFLVSRF SPNEWHLSEA HHSYIANDFS
     ISNSLWFSLG AFMQQGCDIS PRSMSGRIVG SVWWFFTLII ISSYTANLAA FLTVERMLTP
     IDSAEDLARQ TEIQYGTIMS GSTKAFFKNS QFQTYQRMWA YMTSAQPSVF VKTHEEGIQR
     VRQSNGKYAY LTESSTIDYV SNRKPCDTLK VGSNLNSDGF GIGTPVGSDL RDKLNFSVLE
     LRENGDLAKW EKIWFDRGEC PQHSSNKEGA QSALTLANVA GIFYILIGGL VVAVLSAAFE
     FLYKSRMDSR KSRMSFGSAL RTKARLSFKG HIDSEQKTTG NGTRRRSHNS VTYTYTGPTN
     VMGGSHAFED SNTHTEV