GLRX1_VACCW
ID GLRX1_VACCW Reviewed; 108 AA.
AC P68692; P20818;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 29-SEP-2021, entry version 86.
DE RecName: Full=Glutaredoxin-1;
GN OrderedLocusNames=VACWR069; ORFNames=O2L;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND
RP CHARACTERIZATION.
RX PubMed=1496000; DOI=10.1073/pnas.89.15.7060;
RA Ahn B.-Y., Moss B.;
RT "Glutaredoxin homolog encoded by vaccinia virus is a virion-associated
RT enzyme with thioltransferase and dehydroascorbate reductase activities.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:7060-7064(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Displays thioltransferase and dehydroascorbate reductase
CC activities.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:1496000}.
CC Note=Localizes to the virion core. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR EMBL; M76472; AAA48249.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89348.1; -; Genomic_DNA.
DR PIR; E42510; E42510.
DR RefSeq; YP_232951.1; NC_006998.1.
DR BMRB; P68692; -.
DR SMR; P68692; -.
DR DNASU; 3707602; -.
DR GeneID; 3707602; -.
DR KEGG; vg:3707602; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR GO; GO:0004362; F:glutathione-disulfide reductase (NADPH) activity; IEA:InterPro.
DR InterPro; IPR011767; GLR_AS.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR011899; Glutaredoxin_euk/vir.
DR InterPro; IPR014025; Glutaredoxin_subgr.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00462; Glutaredoxin; 1.
DR PRINTS; PR00160; GLUTAREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02180; GRX_euk; 1.
DR PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Electron transport; Redox-active center;
KW Reference proteome; Transport; Virion.
FT CHAIN 1..108
FT /note="Glutaredoxin-1"
FT /id="PRO_0000141618"
FT DOMAIN 3..106
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT DISULFID 23..26
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 108 AA; 12355 MW; 8C754AE57D7F54D4 CRC64;
MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENELRDY
FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC