GLRX1_VARV
ID GLRX1_VARV Reviewed; 108 AA.
AC P0DOR0; P32983; Q76Q32;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 1.
DT 29-SEP-2021, entry version 11.
DE RecName: Full=Glutaredoxin-1;
GN ORFNames=O2L;
OS Variola virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10255;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bangladesh-1975;
RX PubMed=8264798; DOI=10.1038/366748a0;
RA Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT "Potential virulence determinants in terminal regions of variola smallpox
RT virus genome.";
RL Nature 366:748-751(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Garcia-1966;
RX PubMed=10639322; DOI=10.1006/viro.1999.0086;
RA Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V.,
RA Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.;
RT "Alastrim smallpox variola minor virus genome DNA sequences.";
RL Virology 266:361-386(2000).
CC -!- FUNCTION: Displays thioltransferase and dehydroascorbate reductase
CC activities. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Note=Localizes to the virion core.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L22579; AAA60802.1; -; Genomic_DNA.
DR EMBL; Y16780; CAB54654.1; -; Genomic_DNA.
DR PIR; D72157; D72157.
DR PIR; T28492; T28492.
DR RefSeq; NP_042098.1; NC_001611.1.
DR SMR; P0DOR0; -.
DR GeneID; 1486484; -.
DR KEGG; vg:1486484; -.
DR Proteomes; UP000111493; Genome.
DR Proteomes; UP000119805; Genome.
DR GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR GO; GO:0004362; F:glutathione-disulfide reductase (NADPH) activity; IEA:InterPro.
DR InterPro; IPR011767; GLR_AS.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR011899; Glutaredoxin_euk/vir.
DR InterPro; IPR014025; Glutaredoxin_subgr.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00462; Glutaredoxin; 1.
DR PRINTS; PR00160; GLUTAREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02180; GRX_euk; 1.
DR PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Electron transport; Redox-active center; Transport; Virion.
FT CHAIN 1..108
FT /note="Glutaredoxin-1"
FT /id="PRO_0000448107"
FT DOMAIN 3..106
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT DISULFID 23..26
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 108 AA; 12349 MW; 6C7601B104975963 CRC64;
MAEEFVQQRL TNNKVTIFVK FTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENKLHDY
FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC