ID   GLRX2_SYNY3             Reviewed;          88 AA.
AC   P73492;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Probable glutaredoxin ssr2061;
GN   OrderedLocusNames=ssr2061;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the
CC       presence of NADPH and glutathione reductase. Reduces low molecular
CC       weight disulfides and proteins (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P73492; Q55980: sll0662; NbExp=2; IntAct=EBI-6405758, EBI-6405750;
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA17532.1; -; Genomic_DNA.
DR   PIR; S77429; S77429.
DR   PDB; 3QMX; X-ray; 1.82 A; A=2-88.
DR   PDB; 4MJA; X-ray; 2.00 A; A=2-88.
DR   PDB; 4MJB; X-ray; 2.11 A; A=2-88.
DR   PDB; 4MJC; X-ray; 1.41 A; A=2-88.
DR   PDB; 4MJE; X-ray; 1.20 A; A=2-88.
DR   PDBsum; 3QMX; -.
DR   PDBsum; 4MJA; -.
DR   PDBsum; 4MJB; -.
DR   PDBsum; 4MJC; -.
DR   PDBsum; 4MJE; -.
DR   AlphaFoldDB; P73492; -.
DR   SMR; P73492; -.
DR   IntAct; P73492; 2.
DR   STRING; 1148.1652611; -.
DR   PaxDb; P73492; -.
DR   EnsemblBacteria; BAA17532; BAA17532; BAA17532.
DR   KEGG; syn:ssr2061; -.
DR   eggNOG; COG0695; Bacteria.
DR   InParanoid; P73492; -.
DR   OMA; GRTTFPQ; -.
DR   PhylomeDB; P73492; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0015038; F:glutathione disulfide oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0004362; F:glutathione-disulfide reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   CDD; cd03418; GRX_GRXb_1_3_like; 1.
DR   InterPro; IPR011767; GLR_AS.
DR   InterPro; IPR002109; Glutaredoxin.
DR   InterPro; IPR014025; Glutaredoxin_subgr.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR011900; GRX_bact.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00462; Glutaredoxin; 1.
DR   PRINTS; PR00160; GLUTAREDOXIN.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02181; GRX_bact; 1.
DR   PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..88
FT                   /note="Probable glutaredoxin ssr2061"
FT                   /id="PRO_0000141598"
FT   DISULFID        15..18
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
FT   STRAND          7..11
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   HELIX           16..28
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   STRAND          33..36
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   HELIX           41..50
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   TURN            51..53
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   STRAND          59..62
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   STRAND          65..69
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   HELIX           70..78
FT                   /evidence="ECO:0007829|PDB:4MJE"
FT   HELIX           82..86
FT                   /evidence="ECO:0007829|PDB:4MJE"
SQ   SEQUENCE   88 AA;  9735 MW;  4F0588531B0ECCB6 CRC64;
     MAVSAKIEIY TWSTCPFCMR ALALLKRKGV EFQEYCIDGD NEAREAMAAR ANGKRSLPQI
     FIDDQHIGGC DDIYALDGAG KLDPLLHS