ID   GLRX2_VACCT             Reviewed;         124 AA.
AC   Q77TL3;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Glutaredoxin-2;
GN   ORFNames=TG4R;
OS   Vaccinia virus (strain Tian Tan) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10253;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jin Q., Hou Y.D., Cheng N.H., Yao E.M., Cheng S.X., Yang X.K., Jing D.Y.,
RA   Yu W.H., Yuan J.S., Ma X.J.;
RT   "Complete genomic sequence of vaccinia virus (Tian Tan strain).";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Glutaredoxin necessary for virion morphogenesis and virus
CC       replication. Redox shuttle between membrane-associated E10R and L1R or
CC       F9L. Exhibits thioltransferase and dehydroascorbate reductase
CC       activities in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR   EMBL; AF095689; AAF33941.1; -; Genomic_DNA.
DR   SMR; Q77TL3; -.
DR   Proteomes; UP000163220; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008554; Glutaredoxin-like.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF05768; Glrx-like; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Electron transport; Host cytoplasm; Redox-active center;
KW   Transport.
FT   CHAIN           1..124
FT                   /note="Glutaredoxin-2"
FT                   /id="PRO_0000141628"
FT   DISULFID        13..16
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  14000 MW;  DFA2DF7B3A1A9CA6 CRC64;
     MKNVLIIFGK PYCSICENVS DAVEELKSEY DILHVDILSF FLKDGDSSML GDVKRGTLIG
     NFAAHLSNYI VSIFKYNPQT KQMAFVDINK SLDFTKTDKS LVNLEILKSE IEKANYGVWP
     PVTE