ID   AMIC_STRPN              Reviewed;         498 AA.
AC   P0A4M7; P18793;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Oligopeptide transport system permease protein AmiC;
GN   Name=amiC; OrderedLocusNames=SP_1890;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R6 / R800;
RX   PubMed=2352474; DOI=10.1111/j.1365-2958.1990.tb00632.x;
RA   Alloing G., Trombe M.C., Claverys J.-P.;
RT   "The ami locus of the Gram-positive bacterium Streptococcus pneumoniae is
RT   similar to binding protein-dependent transport operons of Gram-negative
RT   bacteria.";
RL   Mol. Microbiol. 4:633-644(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       oligopeptides; probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; X17337; CAA35214.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK75961.1; -; Genomic_DNA.
DR   PIR; H95220; H95220.
DR   PIR; S11150; S11150.
DR   RefSeq; WP_000759901.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A4M7; -.
DR   SMR; P0A4M7; -.
DR   STRING; 170187.SP_1890; -.
DR   EnsemblBacteria; AAK75961; AAK75961; SP_1890.
DR   GeneID; 60232830; -.
DR   KEGG; spn:SP_1890; -.
DR   eggNOG; COG0601; Bacteria.
DR   OMA; TIIYTMV; -.
DR   PhylomeDB; P0A4M7; -.
DR   BioCyc; SPNE170187:G1FZB-1920-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="Oligopeptide transport system permease protein AmiC"
FT                   /id="PRO_0000059943"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          280..479
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   498 AA;  55623 MW;  B9B30A794C3B52DC CRC64;
     MKKYIFMRVL RSLVSIFLVT TLTYTIIYTL VPRKLIFKQD PNYNKIATTA DKRDNYENTV
     FERMGYIEYY DTKELQEKAS SMDSSVTVEA NATNKAIYEK YINQLGHGWT LGEFTESGQF
     YATREIPIFE RVFHFYANLI DIDHTNKIQD PENPDLKRYL RFENDPAIGW SLVGSGTKHK
     YLLYFNSQFP FVHQNFVNLN LGDSYPTYAN TPVLQVITQG QGQTKTAQVQ FPTGKKTSSV
     NIYSRTYKSP SQADSREVAS YGKDDPYTAT ESNYQYPSMI VSSAITGLIG LVLAYALAVP
     LGSAMARFKN TWIDSLSTGA LTFLLALPTI ALVYIVRLIG SSIALPDSFP ILGAGDWRSY
     VLPAVILGLL GAPGTAIWIR RYMIDLQSQD FVRFARAKGL SEKEISNKHI FKNAMVPLVS
     GIPAAIIGVI GGATLTETVF AFPGMGKMLI DSVKASNNSM VVGLVFIFTC ISIFSRLLGD
     IWMTIIDPRI KLTEKGGK