3S13_NAJHA
ID 3S13_NAJHA Reviewed; 61 AA.
AC P01420;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Short neurotoxin 3;
DE AltName: Full=Toxin CM-10;
DE AltName: Full=Toxin V-NH-I1;
OS Naja annulifera (Banded Egyptian cobra) (Naja haje annulifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=96794;
RN [1]
RP PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RA Joubert F.J.;
RT "The amino acid sequences of three toxins (CM-10, CM-12 and CM-14) from
RT Naja haje annulifera (Egyptian cobra) venom.";
RL Hoppe-Seyler's Z. Physiol. Chem. 356:53-72(1975).
CC -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC inhibit acetylcholine from binding to the receptor, thereby impairing
CC neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- TOXIC DOSE: LD(50) is 5.0 mg/kg by subcutaneous injection.
CC {ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR PIR; A01689; N1NJ3E.
DR AlphaFoldDB; P01420; -.
DR SMR; P01420; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 1: Evidence at protein level;
KW Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Toxin.
FT CHAIN 1..61
FT /note="Short neurotoxin 3"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000093598"
FT DISULFID 3..23
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 17..40
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 42..53
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 54..59
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ SEQUENCE 61 AA; 6885 MW; 3A97EAF4B286247B CRC64;
MICYKQQSLQ FPITTVCPGE KNCYKKQWSG HRGTIIERGC GCPSVKKGIE INCCTTDKCN
R
