ID   GLST_MYCTA              Reviewed;         326 AA.
AC   A5U275;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Glycolipid sulfotransferase MRA_1383;
DE            EC=2.8.2.-;
GN   OrderedLocusNames=MRA_1383;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
RN   [2]
RP   SULFOTRANSFERASE ACTIVITY.
RX   PubMed=11882713; DOI=10.1099/00221287-148-3-783;
RA   Rivera-Marrero C.A., Ritzenthaler J.D., Newburn S.A., Roman J.,
RA   Cummings R.D.;
RT   "Molecular cloning and expression of a novel glycolipid sulfotransferase in
RT   Mycobacterium tuberculosis.";
RL   Microbiology 148:783-792(2002).
CC   -!- FUNCTION: Involved in the synthesis of cell wall sulfolipids.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ73125.1; -; Genomic_DNA.
DR   RefSeq; WP_003898849.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U275; -.
DR   SMR; A5U275; -.
DR   STRING; 419947.MRA_1383; -.
DR   EnsemblBacteria; ABQ73125; ABQ73125; MRA_1383.
DR   KEGG; mra:MRA_1383; -.
DR   eggNOG; ENOG502ZA0J; Bacteria.
DR   HOGENOM; CLU_027239_3_0_11; -.
DR   OMA; HANLNRR; -.
DR   OrthoDB; 1555988at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Transferase.
FT   CHAIN           1..326
FT                   /note="Glycolipid sulfotransferase MRA_1383"
FT                   /id="PRO_0000315392"
FT   ACT_SITE        97
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         40..45
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
FT   BINDING         116..124
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  37006 MW;  6BEF3A738E2BDBE6 CRC64;
     MNSEHPMTDR VVYRSLMADN LRWDALQLRD GDIIISAPSK SGLTWTQRLV SLLVFDGPDL
     PGPLSTVSPW LDQTIRPIEE VVATLDAQQH RRFIKTHTPL DGLVLDDRVS YICVGRDPRD
     AAVSMLYQSA NMNEDRMRIL HEAVVPFHER IAPPFAELGH ARSPTEEFRD WMEGPNQPPP
     GIGFTHLKGI GTLANILHQL GTVWVRRHLP NVALFHYADY QADLAGELLR PARVLGIAAT
     RDRARDLAQY ATLDAMRSRA SEIAPNTTDG IWHSDERFFR RGGSGDWQQF FTEAEHLRYY
     HRINQLAPPD LLAWAHEGRR GYDPAN