ID   GLST_MYCTO              Reviewed;         326 AA.
AC   P9WGB8; L0T6N8; P71801; Q8VK27;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Glycolipid sulfotransferase MT1418;
DE            EC=2.8.2.-;
GN   OrderedLocusNames=MT1418;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Involved in the synthesis of cell wall sulfolipids with
CC       activity towards mycobacterial trehalose glycolipids and eukaryotic
CC       glycolipids such as glucosylceramide and galactosylceramide (type I and
CC       II) but not towards eukaryotic 3'-sulfate galactosylceramide.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45682.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK45682.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70958; B70958.
DR   RefSeq; WP_003917467.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGB8; -.
DR   SMR; P9WGB8; -.
DR   EnsemblBacteria; AAK45682; AAK45682; MT1418.
DR   KEGG; mtc:MT1418; -.
DR   PATRIC; fig|83331.31.peg.1525; -.
DR   HOGENOM; CLU_027239_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Transferase.
FT   CHAIN           1..326
FT                   /note="Glycolipid sulfotransferase MT1418"
FT                   /id="PRO_0000428389"
FT   ACT_SITE        97
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         40..45
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
FT   BINDING         116..124
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  36975 MW;  CBFE3A729E3A1086 CRC64;
     MNSEHPMTDR VVYRSLMADN LRWDALQLRD GDIIISAPSK SGLTWTQRLV SLLVFDGPDL
     PGPLSTVSPW LDQTIRPIEE VVATLDAQQH RRFIKTHTPL DGLVLDDRVS YICVGRDPRD
     AAVSMLYQSA NMNEDRMRIL HEAVVPFHER IAPPFAELGH ARSPTEEFRD WMEGPNPPPP
     GIGFTHLKGI GTLANILHQL GTVWVRRHLP NVALFHYADY QADLAGELLR PARVLGIAAT
     RDRARDLAQY ATLDAMRSRA SEIAPNTTDG IWHSDERFFR RGGSGDWQQF FTEAEHLRYY
     HRINQLAPPD LLAWAHEGRR GYDPAN