ID   GLST_MYCTU              Reviewed;         326 AA.
AC   P9WGB9; L0T6N8; P71801; Q8VK27;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Glycolipid sulfotransferase Rv1373;
DE            EC=2.8.2.-;
GN   OrderedLocusNames=Rv1373;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION AS A SULFOTRANSFERASE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11882713; DOI=10.1099/00221287-148-3-783;
RA   Rivera-Marrero C.A., Ritzenthaler J.D., Newburn S.A., Roman J.,
RA   Cummings R.D.;
RT   "Molecular cloning and expression of a novel glycolipid sulfotransferase in
RT   Mycobacterium tuberculosis.";
RL   Microbiology 148:783-792(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Involved in the synthesis of cell wall sulfolipids with
CC       activity towards mycobacterial trehalose glycolipids and eukaryotic
CC       glycolipids such as glucosylceramide and galactosylceramide (type I and
CC       II) but not towards eukaryotic 3'-sulfate galactosylceramide.
CC       {ECO:0000269|PubMed:11882713}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44132.1; -; Genomic_DNA.
DR   PIR; B70958; B70958.
DR   RefSeq; NP_215889.1; NC_000962.3.
DR   RefSeq; WP_003898849.1; NZ_NVQJ01000050.1.
DR   AlphaFoldDB; P9WGB9; -.
DR   SMR; P9WGB9; -.
DR   STRING; 83332.Rv1373; -.
DR   PaxDb; P9WGB9; -.
DR   DNASU; 886781; -.
DR   GeneID; 886781; -.
DR   KEGG; mtu:Rv1373; -.
DR   PATRIC; fig|83332.111.peg.1533; -.
DR   TubercuList; Rv1373; -.
DR   eggNOG; ENOG502ZA0J; Bacteria.
DR   OMA; HANLNRR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008146; F:sulfotransferase activity; IDA:MTBBASE.
DR   GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR   GO; GO:0046506; P:sulfolipid biosynthetic process; IDA:MTBBASE.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..326
FT                   /note="Glycolipid sulfotransferase Rv1373"
FT                   /id="PRO_0000315390"
FT   ACT_SITE        97
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         40..45
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
FT   BINDING         116..124
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  37006 MW;  6BEF3A738E2BDBE6 CRC64;
     MNSEHPMTDR VVYRSLMADN LRWDALQLRD GDIIISAPSK SGLTWTQRLV SLLVFDGPDL
     PGPLSTVSPW LDQTIRPIEE VVATLDAQQH RRFIKTHTPL DGLVLDDRVS YICVGRDPRD
     AAVSMLYQSA NMNEDRMRIL HEAVVPFHER IAPPFAELGH ARSPTEEFRD WMEGPNQPPP
     GIGFTHLKGI GTLANILHQL GTVWVRRHLP NVALFHYADY QADLAGELLR PARVLGIAAT
     RDRARDLAQY ATLDAMRSRA SEIAPNTTDG IWHSDERFFR RGGSGDWQQF FTEAEHLRYY
     HRINQLAPPD LLAWAHEGRR GYDPAN