ID   GLT25_AEDAE             Reviewed;         607 AA.
AC   Q17FB8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Glycosyltransferase 25 family member;
DE            EC=2.-.-.-;
DE   Flags: Precursor;
GN   ORFNames=AAEL003481;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477272; EAT45228.1; -; Genomic_DNA.
DR   RefSeq; XP_001656834.1; XM_001656784.1.
DR   AlphaFoldDB; Q17FB8; -.
DR   SMR; Q17FB8; -.
DR   STRING; 7159.AAEL003481-PA; -.
DR   GeneID; 5578193; -.
DR   KEGG; aag:5578193; -.
DR   VEuPathDB; VectorBase:AAEL003481; -.
DR   eggNOG; KOG4179; Eukaryota.
DR   HOGENOM; CLU_024037_2_0_1; -.
DR   InParanoid; Q17FB8; -.
DR   OMA; KRTGCFA; -.
DR   OrthoDB; 256590at2759; -.
DR   PhylomeDB; Q17FB8; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF01755; Glyco_transf_25; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase;
KW   Reference proteome; Signal; Transferase.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..607
FT                   /note="Glycosyltransferase 25 family member"
FT                   /id="PRO_0000309547"
FT   REGION          566..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           604..607
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        568..582
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        226
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        514
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        565
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   607 AA;  70212 MW;  7AEACE2EBA1F4747 CRC64;
     MKPVSCVGLL VLLVGVLVTV KGSILFQSPK VLIVSLIRNK EHTLPYFFSY LEDQEYPKDR
     ISLWFRSDHN EDRSIDIIKA WLKRVTKKYH SVDFGYRSDA AKRYDEKSST HWSEDRFADV
     IRLKQEALDK GRKMWADFVL FLDADVLLTN PNTIAKLVSL NLPIVAPMLL SDGLYSNFWC
     GMTADYYYHR TDEYKEILNY EKTGEFPVPM VHSAVMVNIN VQQSLNLSFD KRRLPPGHYT
     GPVDDIIIFA MSANYSSIPM YISNSASYGY ILVPLEQGDP LEKDLEQLTN TKVYIINEHG
     AINLKEDLKH FVPKVPKDKM GVSHIYMINL ERRPERRNKM FNNFDELGLD VEFFPAVDGR
     QLSDDKLRDI GVKFLPGYAD PYHKRPMTMG EIGCFLSHYY IWEKMVAMNQ EEVLVLEDDI
     RFEPYFKRRV AQVLDDARRI GGWDLIYFGR KRLQEDDEKW VVGSETLVVA GYSYWTLGYL
     ISLQGAKKLL EEKPLEKLVP VDEYIPIMFN NHPNESWVNH FKNRNLVAWS AAPLLLYPTH
     YTGDDGYISD TEDSARIDNF NKVLNDTSDS SAEKKGDKEQ LSSKTLMDST ISRDEHELSV
     ANRKSEL