ID   GLT25_ANOGA             Reviewed;         592 AA.
AC   Q7Q021;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 4.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Glycosyltransferase 25 family member;
DE            EC=2.-.-.-;
DE   Flags: Precursor;
GN   ORFNames=AGAP012208;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA00118.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAAB01008986; EAA00118.3; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_320324.3; XM_320324.4.
DR   AlphaFoldDB; Q7Q021; -.
DR   SMR; Q7Q021; -.
DR   STRING; 7165.AGAP012208-PA; -.
DR   PaxDb; Q7Q021; -.
DR   GeneID; 1280478; -.
DR   KEGG; aga:AgaP_AGAP012208; -.
DR   CTD; 1280478; -.
DR   VEuPathDB; VectorBase:AGAP012208; -.
DR   eggNOG; KOG4179; Eukaryota.
DR   HOGENOM; CLU_024037_2_0_1; -.
DR   InParanoid; Q7Q021; -.
DR   OrthoDB; 256590at2759; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0050211; F:procollagen galactosyltransferase activity; IBA:GO_Central.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF01755; Glyco_transf_25; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase;
KW   Reference proteome; Signal; Transferase.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..592
FT                   /note="Glycosyltransferase 25 family member"
FT                   /id="PRO_0000309548"
FT   REGION          552..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           589..592
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        249
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        510
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   592 AA;  68811 MW;  99FD2456BEAD5615 CRC64;
     MLALLLTTTI VSGDNQIELT EQLPTVMVAV LVRNKAHTLP YFFSYLEDLD YPKDRMSLWI
     RSDHNEDRSI EITKAWLKRT SSLYHSVDFK YRSERGKRES EKTSTHWNEE RFSDVIRLKQ
     DALQAARMMW ADYIFFIDAD VFLTNSNTLG KLIERKLPIV APMLVSDGLY SNFWCGMTSD
     YYYQRTDDYK KILNYDQIGQ WPVPMVHTAV LVSLNIAQTR QLTFERKNLP VGRYDGPVDD
     IIIFAMSANY SGIPMYVCNE LLYGYIMVPL EAGETVPGKD LEQLTNVLSY IVNEYGALSL
     KQDLSRFVAD VPKDKLSLSH IYMINLERRT ERRTKMLKHF DLLGLDVEHF PAVDGKQLSD
     KKVYDMGIRF LPGYADPFHK RPMTMGEIGC FLSHYNIWER MVRLNQQEVL VLEDDIRFEP
     FFRRRAYGVL ADARRIGGWD LIYFGRKRLQ EEDEKWIDGS EYLVKAGYSY WTLGYVITLE
     GAKKLLREQP LSKLLPVDEY LPIMFDNHPN ESWTSHFRDR TLSAWSAAPL LLYPTHYTGD
     EGYISDTEDS LRIQEPKKGD KEQLPNAPAL LSESGIGQGE HDLETKNRRS EL