ID   GLT25_DROPS             Reviewed;         626 AA.
AC   Q29NU5; I5AMN0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Glycosyltransferase 25 family member;
DE            EC=2.-.-.-;
DE   Flags: Precursor;
GN   ORFNames=GA16561;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-
CC       ProRule:PRU10138}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
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DR   EMBL; CH379058; EIM52215.1; -; Genomic_DNA.
DR   RefSeq; XP_003736142.1; XM_003736094.2.
DR   AlphaFoldDB; Q29NU5; -.
DR   SMR; Q29NU5; -.
DR   STRING; 7237.FBpp0291201; -.
DR   EnsemblMetazoa; FBtr0301991; FBpp0291201; FBgn0076576.
DR   GeneID; 4818107; -.
DR   KEGG; dpo:Dpse_GA16561; -.
DR   eggNOG; KOG4179; Eukaryota.
DR   HOGENOM; CLU_024037_2_0_1; -.
DR   InParanoid; Q29NU5; -.
DR   OMA; KRTGCFA; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0076576; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF01755; Glyco_transf_25; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase;
KW   Reference proteome; Signal; Transferase.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..626
FT                   /note="Glycosyltransferase 25 family member"
FT                   /id="PRO_0000309550"
FT   MOTIF           623..626
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10138"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        234
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        272
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   626 AA;  72334 MW;  85B74CDB5474ECDE CRC64;
     MLKKQVFYGI LLICAFVCIY GEDEDEKEAQ DEYQPPTVLV ALLVRNKAHI LPMFLSYLEQ
     QDYPKDRIAF WLRCDHSSDD SIDLLKQWLK HSGDLYHSVN YAFDSDGPHG YQNESSPYDW
     TVSRFKHVIA LKEEAFTYAR DIWADFVFFL DADVLLTSQQ ALRTLTALRL PIVAPMLLSE
     SLYSNFWCGM TEEYYYQRTD EYKEIYHVKK QGSFPVPMVH TAVLVDMNHK GARNLTFDRQ
     RLRDIQQSNQ QLDQPLYEGP ADDIIVFAMS ANSSGIPLHV CNELTFGYIL QPLEPGDTLE
     QDLQMLLNIR ASMVSDLGAV PPVLEYFQPL IKTPEKTKLT LDHIFMINLE RRPERRQKME
     NLFEEIGLQV EHFPAVDGKE LNADRVQEMG IRFLPGYEDP YHHRAMTMGE IGCFLSHYRI
     WVRMVQLELK EVLILEDDIR FDPYFRANAV RVLNQARSVV EYDLIYFGRK RLKEESEPWV
     ADADSLVHAG YSYWTLGYVL SLQGALKLLA AKPLEKLIPV DEFLPVMFDR HPNKTWTAAF
     KKRDLIALSA APLLLYPIHY TGESGYISDT EDSQQINVQT TEGVARLKSD REQVFVKKGD
     DGILEQQLKM GESLSNVLPG KTHQEL