GLTB_AZOBR
ID GLTB_AZOBR Reviewed; 1515 AA.
AC Q05755;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Glutamate synthase [NADPH] large chain;
DE EC=1.4.1.13;
DE AltName: Full=Glutamate synthase subunit alpha;
DE Short=GLTS alpha chain;
DE AltName: Full=NADPH-GOGAT;
DE Flags: Precursor;
GN Name=gltB;
OS Azospirillum brasilense.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Azospirillum.
OX NCBI_TaxID=192;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 37-56; 778-799
RP AND 1325-1345.
RC STRAIN=ATCC 29145 / DSM 1690 / IMET 11303 / Sp7;
RX PubMed=8428988; DOI=10.1016/s0021-9258(18)53664-4;
RA Pelanda R., Vanoni M.A., Perego M., Piubelli L., Galizzi A., Curti B.,
RA Zanetti G.;
RT "Glutamate synthase genes of the diazotroph Azospirillum brasilense.
RT Cloning, sequencing, and analysis of functional domains.";
RL J. Biol. Chem. 268:3099-3106(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 834-927.
RC STRAIN=RG;
RX PubMed=7902833; DOI=10.1128/jb.175.24.8024-8029.1993;
RA Mandal A.K., Ghosh S.;
RT "Isolation of a glutamate synthase (GOGAT)-negative, pleiotropically N
RT utilization-defective mutant of Azospirillum brasilense: cloning and
RT partial characterization of GOGAT structural gene.";
RL J. Bacteriol. 175:8024-8029(1993).
RN [3]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=2198943; DOI=10.1016/0167-4838(90)90273-i;
RA Vanoni M.A., Negri A., Zanetti G., Ronchi S., Curti B.;
RT "Structural studies on the subunits of glutamate synthase from Azospirillum
RT brasilense.";
RL Biochim. Biophys. Acta 1039:374-377(1990).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine
CC + NADPH; Xref=Rhea:RHEA:15501, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58359; EC=1.4.1.13;
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Note=Binds 1 [3Fe-4S] cluster.;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC -!- PATHWAY: Amino-acid biosynthesis; L-glutamate biosynthesis via GLT
CC pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+)
CC route): step 1/1.
CC -!- PATHWAY: Energy metabolism; nitrogen metabolism.
CC -!- SUBUNIT: Aggregate of 4 catalytic active heterodimers, consisting of a
CC large and a small subunit.
CC -!- MISCELLANEOUS: Glutamine binds to the large subunit and transfers the
CC amido group to 2-oxo-glutamate that apparently binds to the small
CC subunit.
CC -!- SIMILARITY: Belongs to the glutamate synthase family. {ECO:0000305}.
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DR EMBL; AF192408; AAA22179.1; -; Genomic_DNA.
DR EMBL; X71632; CAA50639.1; -; Genomic_DNA.
DR PIR; B46602; B46602.
DR PDB; 1EA0; X-ray; 3.00 A; A/B=37-1515.
DR PDB; 2VDC; EM; 9.50 A; A/B/C/D/E/F=37-1508.
DR PDB; 6S6S; EM; 3.90 A; A/B/C/D=1-1515.
DR PDB; 6S6T; EM; 4.10 A; A/B/C/D=1-1515.
DR PDB; 6S6U; EM; 3.50 A; A/B/C/D/E/F=1-1515.
DR PDB; 6S6X; EM; 3.50 A; A/B/C/D/E/F=1-1515.
DR PDBsum; 1EA0; -.
DR PDBsum; 2VDC; -.
DR PDBsum; 6S6S; -.
DR PDBsum; 6S6T; -.
DR PDBsum; 6S6U; -.
DR PDBsum; 6S6X; -.
DR AlphaFoldDB; Q05755; -.
DR SASBDB; Q05755; -.
DR SMR; Q05755; -.
DR MEROPS; C44.003; -.
DR PRIDE; Q05755; -.
DR KEGG; ag:AAA22179; -.
DR BioCyc; MetaCyc:MON-13079; -.
DR BRENDA; 1.4.1.13; 611.
DR UniPathway; UPA00045; -.
DR UniPathway; UPA00634; UER00689.
DR EvolutionaryTrace; Q05755; -.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004355; F:glutamate synthase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0097054; P:L-glutamate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00982; gltB_C; 1.
DR CDD; cd02808; GltS_FMN; 1.
DR Gene3D; 2.160.20.60; -; 1.
DR Gene3D; 3.20.20.70; -; 2.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR002489; Glu_synth_asu_C.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR InterPro; IPR006982; Glu_synth_centr_N.
DR InterPro; IPR002932; Glu_synthdom.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR Pfam; PF00310; GATase_2; 1.
DR Pfam; PF04898; Glu_syn_central; 1.
DR Pfam; PF01645; Glu_synthase; 1.
DR Pfam; PF01493; GXGXG; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR SUPFAM; SSF69336; SSF69336; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; 3Fe-4S; Amino-acid biosynthesis; Direct protein sequencing;
KW FAD; Flavoprotein; FMN; Glutamate biosynthesis; Glutamine amidotransferase;
KW Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Zymogen.
FT PROPEP 1..36
FT /evidence="ECO:0000269|PubMed:8428988"
FT /id="PRO_0000011618"
FT CHAIN 37..1515
FT /note="Glutamate synthase [NADPH] large chain"
FT /id="PRO_0000011619"
FT DOMAIN 37..432
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
FT REGION 916..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 37
FT /note="For GATase activity"
FT /evidence="ECO:0000250"
FT BINDING 1085..1142
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
FT BINDING 1086..1142
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
FT BINDING 1138
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 1144
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 1149
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 51..61
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 65..67
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 72..75
FT /evidence="ECO:0007829|PDB:6S6U"
FT STRAND 82..85
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 107..114
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 119..135
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 139..145
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 155..160
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 163..170
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 177..198
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 204..214
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 221..223
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 224..227
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 229..232
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 233..235
FT /evidence="ECO:0007829|PDB:6S6U"
FT STRAND 238..245
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 249..251
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 255..257
FT /evidence="ECO:0007829|PDB:6S6U"
FT STRAND 262..268
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 273..283
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 284..286
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 290..292
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 293..295
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 296..299
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 309..322
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 327..334
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 342..345
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 347..359
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 365..371
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 373..380
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 390..394
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 397..401
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 403..405
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 412..414
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 415..420
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 426..430
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 431..434
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 435..437
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 439..448
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 449..451
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 452..456
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 464..471
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 481..488
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 489..491
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 494..498
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 499..501
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 502..507
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 522..524
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 531..533
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 535..537
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 542..544
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 549..552
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 553..555
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 560..563
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 573..575
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 578..582
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 584..586
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 588..598
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 599..601
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 602..606
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 608..611
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 617..635
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 639..643
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 651..653
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 656..668
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 669..671
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 673..675
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 677..681
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 688..695
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 696..698
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 700..703
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 705..715
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 716..722
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 725..745
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 746..748
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 752..755
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 761..766
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 768..774
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 775..777
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 787..802
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 814..816
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 819..822
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 828..840
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 843..854
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 861..864
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 865..867
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 876..878
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 882..886
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 889..893
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 896..898
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 901..913
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 917..919
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 927..929
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 930..932
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 934..936
FT /evidence="ECO:0007829|PDB:6S6U"
FT STRAND 942..946
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 955..958
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 962..967
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 971..973
FT /evidence="ECO:0007829|PDB:6S6U"
FT TURN 974..976
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 982..984
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 987..993
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1013..1026
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1031..1037
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1042..1051
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1055..1060
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1067..1070
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1073..1076
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1081..1093
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1094..1096
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1100..1108
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1112..1120
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1124..1127
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1130..1136
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1144..1147
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1152..1154
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1160..1162
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1168..1189
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1195..1197
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1201..1203
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1204..1206
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1211..1213
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 1220..1223
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1248..1254
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1256..1261
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1265..1271
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1280..1289
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1290..1293
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1299..1308
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1312..1315
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1320..1328
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1332..1335
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1337..1344
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1353..1355
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1356..1359
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1363..1366
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1369..1378
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1380..1385
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1387..1394
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1400..1403
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1406..1409
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1417..1419
FT /evidence="ECO:0007829|PDB:1EA0"
FT TURN 1420..1422
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1425..1428
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1433..1435
FT /evidence="ECO:0007829|PDB:6S6U"
FT HELIX 1437..1440
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1443..1445
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1446..1449
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1456..1471
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1474..1481
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1483..1487
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1492..1495
FT /evidence="ECO:0007829|PDB:1EA0"
FT HELIX 1496..1501
FT /evidence="ECO:0007829|PDB:1EA0"
FT STRAND 1502..1504
FT /evidence="ECO:0007829|PDB:6S6X"
SQ SEQUENCE 1515 AA; 166018 MW; ED913218DBFCEE92 CRC64;
MTTELNQGEQ FVADFRANAA ALTTANAYNP EDEHDACGVG FIAAIDGKPR RSVVEKGIEA
LKAVWHRGAV DADGKTGDGA GIHVAVPQKF FKDHVKVIGH RAPDNKLAVG QVFLPRISLD
AQEACRCIVE TEILAFGYYI YGWRQVPINV DIIGEKANAT RPEIEQIIVG NNKGVSDEQF
ELDLYIIRRR IEKAVKGEQI NDFYICSLSA RSIIYKGMFL AEQLTTFYPD LLDERFESDF
AIYHQRYSTN TFPTWPLAQP FRMLAHNGEI NTVKGNVNWM KAHETRMEHP AFGTHMQDLK
PVIGVGLSDS GSLDTVFEVM VRAGRTAPMV KMMLVPQALT SSQTTPDNHK ALIQYCNSVM
EPWDGPAALA MTDGRWVVGG MDRNGLRPMR YTITTDGLII GGSETGMVKI DETQVIEKGR
LGPGEMIAVD LQSGKLYRDR ELKDHLATLK PWDKWVQNTT HLDELVKTAS LKGEPSDMDK
AELRRRQQAF GLTMEDMELI LHPMVEDGKE AIGSMGDDSP IAVLSDKYRG LHHFFRQNFS
QVTNPPIDSL RERRVMSLKT RLGNLGNILD EDETQTRLLQ LESPVLTTAE FRAMRDYMGD
TAAEIDATFP VDGGPEALRD ALRRIRQETE DAVRGGATHV ILTDEAMGPA RAAIPAILAT
GAVHTHLIRS NLRTFTSLNV RTAEGLDTHY FAVLIGVGAT TVNAYLAQEA IAERHRRGLF
GSMPLEKGMA NYKKAIDDGL LKIMSKMGIS VISSYRGGGN FEAIGLSRAL VAEHFPAMVS
RISGIGLNGI QKKVLEQHAT AYNEEVVALP VGGFYRFRKS GDRHGWEGGV IHTLQQAVTN
DSYTTFKKYS EQVNKRPPMQ LRDLLELRST KAPVPVDEVE SITAIRKRFI TPGMSMGALS
PEAHGTLNVA MNRIGAKSDS GEGGEDPARF RPDKNGDNWN SAIKQVASGR FGVTAEYLNQ
CRELEIKVAQ GAKPGEGGQL PGFKVTEMIA RLRHSTPGVM LISPPPHHDI YSIEDLAQLI
YDLKQINPDA KVTVKLVSRS GIGTIAAGVA KANADIILIS GNSGGTGASP QTSIKFAGLP
WEMGLSEVHQ VLTLNRLRHR VRLRTDGGLK TGRDIVIAAM LGAEEFGIGT ASLIAMGCIM
VRQCHSNTCP VGVCVQDDKL RQKFVGTPEK VVNLFTFLAE EVREILAGLG FRSLNEVIGR
TDLLHQVSRG AEHLDDLDLN PRLAQVDPGE NARYCTLQGR NEVPDTLDAR IVADARPLFE
EGEKMQLAYN ARNTQRAIGT RLSSMVTRKF GMFGLQPGHI TIRLRGTAGQ SLGAFAVQGI
KLEVMGDAND YVGKGLSGGT IVVRPTTSSP LETNKNTIIG NTVLYGATAG KLFAAGQAGE
RFAVRNSGAT VVVEGCGSNG CEYMTGGTAV ILGRVGDNFA AGMTGGMAYV YDLDDSLPLY
INDESVIFQR IEVGHYESQL KHLIEEHVTE TQSRFAAEIL NDWAREVTKF WQVVPKEMLN
RLEVPVHLPK AISAE
