ID   GLTD2_HUMAN             Reviewed;         291 AA.
AC   A6NH11; A7E2T2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Glycolipid transfer protein domain-containing protein 2;
GN   Name=GLTPD2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-291.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC109333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150536; AAI50537.1; -; mRNA.
DR   CCDS; CCDS32534.1; -.
DR   AlphaFoldDB; A6NH11; -.
DR   SMR; A6NH11; -.
DR   IntAct; A6NH11; 1.
DR   STRING; 9606.ENSP00000328070; -.
DR   GlyGen; A6NH11; 1 site.
DR   iPTMnet; A6NH11; -.
DR   PhosphoSitePlus; A6NH11; -.
DR   BioMuta; GLTPD2; -.
DR   MassIVE; A6NH11; -.
DR   MaxQB; A6NH11; -.
DR   PaxDb; A6NH11; -.
DR   PeptideAtlas; A6NH11; -.
DR   PRIDE; A6NH11; -.
DR   ProteomicsDB; 1173; -.
DR   Antibodypedia; 11322; 61 antibodies from 14 providers.
DR   Ensembl; ENST00000331264.8; ENSP00000328070.7; ENSG00000182327.8.
DR   MANE-Select; ENST00000331264.8; ENSP00000328070.7; NM_001014985.3; NP_001014985.3.
DR   UCSC; uc002fza.3; human.
DR   GeneCards; GLTPD2; -.
DR   HGNC; HGNC:33756; GLTPD2.
DR   HPA; ENSG00000182327; Tissue enriched (liver).
DR   neXtProt; NX_A6NH11; -.
DR   OpenTargets; ENSG00000182327; -.
DR   PharmGKB; PA162389864; -.
DR   VEuPathDB; HostDB:ENSG00000182327; -.
DR   eggNOG; KOG4189; Eukaryota.
DR   GeneTree; ENSGT00940000162518; -.
DR   HOGENOM; CLU_079649_0_0_1; -.
DR   InParanoid; A6NH11; -.
DR   OMA; KECPGQS; -.
DR   PhylomeDB; A6NH11; -.
DR   TreeFam; TF316097; -.
DR   PathwayCommons; A6NH11; -.
DR   SignaLink; A6NH11; -.
DR   Pharos; A6NH11; Tdark.
DR   PRO; PR:A6NH11; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A6NH11; protein.
DR   Bgee; ENSG00000182327; Expressed in right lobe of liver and 93 other tissues.
DR   Genevisible; A6NH11; HS.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR   GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR   GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR   GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR   Gene3D; 1.10.3520.10; -; 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   Pfam; PF08718; GLTP; 1.
DR   SUPFAM; SSF110004; SSF110004; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Reference proteome.
FT   CHAIN           1..291
FT                   /note="Glycolipid transfer protein domain-containing
FT                   protein 2"
FT                   /id="PRO_0000317162"
FT   CARBOHYD        276
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   CONFLICT        152
FT                   /note="V -> A (in Ref. 2; AAI50537)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209
FT                   /note="D -> E (in Ref. 2; AAI50537)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        265
FT                   /note="V -> L (in Ref. 2; AAI50537)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   291 AA;  31642 MW;  589565F42C5AA13F CRC64;
     MGVAARPPAL RHWFSHSIPL AIFALLLLYL SVRSLGARSG CGPRAQPCVP GETAPFQVRQ
     ESGTLEAPER KQPPCLGPRG MLGRMMRRFH ASLKPEGDVG LSPYLAGWRA LVEFLTPLGS
     VFAFATREAF TKVTDLEARV HGPDAEHYWS LVAMAAWERR AGLLEQPGAA PRDPTRSSGS
     RTLLLLHRAL RWSQLCLHRV ATGALGGPDA GVQCSDAYRA ALGPHHPWLV RQTARLAFLA
     FPGRRRLLEL ACPGATEAEA RAALVRAAGT LEDVYNRTQS LLAERGLLQL A