ID   GLTD2_MOUSE             Reviewed;         321 AA.
AC   Q8K0R6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Glycolipid transfer protein domain-containing protein 2;
GN   Name=Gltpd2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
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DR   EMBL; AK050107; BAC34069.1; -; mRNA.
DR   EMBL; AK050212; BAC34125.1; -; mRNA.
DR   EMBL; AL592547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR933736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC030735; AAH30735.1; -; mRNA.
DR   CCDS; CCDS24952.1; -.
DR   RefSeq; NP_666132.1; NM_146020.1.
DR   AlphaFoldDB; Q8K0R6; -.
DR   SMR; Q8K0R6; -.
DR   STRING; 10090.ENSMUSP00000049732; -.
DR   PhosphoSitePlus; Q8K0R6; -.
DR   jPOST; Q8K0R6; -.
DR   MaxQB; Q8K0R6; -.
DR   PaxDb; Q8K0R6; -.
DR   PeptideAtlas; Q8K0R6; -.
DR   PRIDE; Q8K0R6; -.
DR   ProteomicsDB; 271235; -.
DR   Antibodypedia; 11322; 61 antibodies from 14 providers.
DR   DNASU; 216871; -.
DR   Ensembl; ENSMUST00000057685; ENSMUSP00000049732; ENSMUSG00000046811.
DR   GeneID; 216871; -.
DR   KEGG; mmu:216871; -.
DR   UCSC; uc007jvd.1; mouse.
DR   CTD; 388323; -.
DR   MGI; MGI:2444527; Gltpd2.
DR   VEuPathDB; HostDB:ENSMUSG00000046811; -.
DR   eggNOG; KOG4189; Eukaryota.
DR   GeneTree; ENSGT00940000162518; -.
DR   HOGENOM; CLU_079649_0_0_1; -.
DR   InParanoid; Q8K0R6; -.
DR   OMA; KECPGQS; -.
DR   OrthoDB; 1423493at2759; -.
DR   PhylomeDB; Q8K0R6; -.
DR   TreeFam; TF316097; -.
DR   BioGRID-ORCS; 216871; 2 hits in 75 CRISPR screens.
DR   PRO; PR:Q8K0R6; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8K0R6; protein.
DR   Bgee; ENSMUSG00000046811; Expressed in yolk sac and 27 other tissues.
DR   ExpressionAtlas; Q8K0R6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR   GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR   GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR   GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR   Gene3D; 1.10.3520.10; -; 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   Pfam; PF08718; GLTP; 1.
DR   SUPFAM; SSF110004; SSF110004; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..321
FT                   /note="Glycolipid transfer protein domain-containing
FT                   protein 2"
FT                   /id="PRO_0000317163"
SQ   SEQUENCE   321 AA;  34453 MW;  0ABE72D7C9AC8EFE CRC64;
     MVMGVSLSPA LGRWFRHAIP FAILTLLLLY ISIWFFYEWP FPLPAQRTQQ SGLRGLKLPS
     PSPVLGSLLS FPAGVQSCNP ERPLPSQTGP AARPLVVPEK EELPCLGPHG ALGRMVSPFL
     ACMSPEGDVA LSQYLAGWRE LLRFLTPLGT VFAFATSEAF NKVTDLEARV HGPNASHYTS
     LMTMITWERG AGLLQRPGTE PGHSAGSSGS RTLLLLHRAL RWSQLCLHRV ATGTLGGPDA
     GTQCGEAYST ALAPHHPWLI RQAARLAILA LPSRGRLLQL ACPGTGEADA RVALARAAGV
     LEDVYNRTQG LLAGHGLLQL A