ID   GLTF_ECOLI              Reviewed;         254 AA.
AC   P28721; Q2M8Z8;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein GltF;
DE   Flags: Precursor;
GN   Name=gltF; OrderedLocusNames=b3214, JW3181;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=1447980; DOI=10.1111/j.1365-2958.1992.tb01450.x;
RA   Castano I., Flores N., Valle F., Covarrubias A.A., Bolivar F.;
RT   "gltF, a member of the gltBDF operon of Escherichia coli, is involved in
RT   nitrogen-regulated gene expression.";
RL   Mol. Microbiol. 6:2733-2741(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=19429622; DOI=10.1128/jb.00108-09;
RA   Shimada T., Yamamoto K., Ishihama A.;
RT   "Involvement of the leucine response transcription factor LeuO in
RT   regulation of the genes for sulfa drug efflux.";
RL   J. Bacteriol. 191:4562-4571(2009).
CC   -!- FUNCTION: Involved in induction of the so-called NTR enzymes in
CC       response to nitrogen deprivation, as well as in glutamate biosynthesis.
CC       May mediate the glutamate-dependent repression of the GLT operon.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by H-NS, induced by LeuO. A monocistronic operon.
CC       {ECO:0000269|PubMed:19429622}.
CC   -!- SIMILARITY: To E.coli YhcF. {ECO:0000305}.
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DR   EMBL; M74162; AAA23909.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA58016.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76246.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77258.1; -; Genomic_DNA.
DR   PIR; S25281; S25281.
DR   RefSeq; NP_417681.1; NC_000913.3.
DR   RefSeq; WP_000465371.1; NZ_SSZK01000007.1.
DR   AlphaFoldDB; P28721; -.
DR   BioGRID; 4262941; 9.
DR   BioGRID; 852058; 1.
DR   IntAct; P28721; 3.
DR   STRING; 511145.b3214; -.
DR   PaxDb; P28721; -.
DR   PRIDE; P28721; -.
DR   EnsemblBacteria; AAC76246; AAC76246; b3214.
DR   EnsemblBacteria; BAE77258; BAE77258; BAE77258.
DR   GeneID; 947746; -.
DR   KEGG; ecj:JW3181; -.
DR   KEGG; eco:b3214; -.
DR   PATRIC; fig|1411691.4.peg.3515; -.
DR   EchoBASE; EB1476; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_093407_0_0_6; -.
DR   InParanoid; P28721; -.
DR   OMA; GMTANDE; -.
DR   PhylomeDB; P28721; -.
DR   BioCyc; EcoCyc:EG11514-MON; -.
DR   PRO; PR:P28721; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010546; DUF1120.
DR   Pfam; PF06551; DUF1120; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..254
FT                   /note="Protein GltF"
FT                   /id="PRO_0000021335"
FT   TRANSMEM        213..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   254 AA;  26352 MW;  7424D7D1339A5F27 CRC64;
     MFFKKNLTTA AICAALSVAA FSAMATDSTD TELTIIGEYT PGACTPVVTG GGIVDYGKHH
     NSALNPTGKS NKLVQLGRKN STLNITCTAP TLIAVTSKDN RQSTIVALND TSYIEKAYDT
     LVDMKGTKNA FGLGSAPNGQ KIGAASIGID RSNGGIHAAD DTGEIPVDLI QTDHWSAATP
     TWKASSNGAF CSLTSCSAIE RGYSVAKTGE LTPVAITAVT FPLLIDAAVN DNTILGSDET
     IKLDGNVTIS VQYL