ID   GLTP2_ARATH             Reviewed;         223 AA.
AC   Q6NLQ3; Q9LPL7;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Glycolipid transfer protein 2 {ECO:0000303|PubMed:16309699};
GN   Name=GLTP2 {ECO:0000303|PubMed:16309699};
GN   OrderedLocusNames=At1g21360 {ECO:0000312|Araport:AT1G21360};
GN   ORFNames=F24J8.2 {ECO:0000312|EMBL:AAF87892.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAS76764.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA   Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA   Shinozaki K., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION.
RX   PubMed=16309699; DOI=10.1016/j.jmb.2005.10.031;
RA   Airenne T.T., Kidron H., Nymalm Y., Nylund M., West G., Mattjus P.,
RA   Salminen T.A.;
RT   "Structural evidence for adaptive ligand binding of glycolipid transfer
RT   protein.";
RL   J. Mol. Biol. 355:224-236(2006).
CC   -!- FUNCTION: Transfers glycolipids in vitro.
CC       {ECO:0000305|PubMed:16309699}.
CC   -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF87892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC015447; AAF87892.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE30093.1; -; Genomic_DNA.
DR   EMBL; BT012277; AAS76764.1; -; mRNA.
DR   EMBL; AK221557; BAD94962.1; -; mRNA.
DR   PIR; G86346; G86346.
DR   RefSeq; NP_173558.4; NM_101988.5.
DR   AlphaFoldDB; Q6NLQ3; -.
DR   SMR; Q6NLQ3; -.
DR   STRING; 3702.AT1G21360.1; -.
DR   PaxDb; Q6NLQ3; -.
DR   PRIDE; Q6NLQ3; -.
DR   EnsemblPlants; AT1G21360.1; AT1G21360.1; AT1G21360.
DR   GeneID; 838735; -.
DR   Gramene; AT1G21360.1; AT1G21360.1; AT1G21360.
DR   KEGG; ath:AT1G21360; -.
DR   Araport; AT1G21360; -.
DR   TAIR; locus:2027042; AT1G21360.
DR   eggNOG; KOG3221; Eukaryota.
DR   HOGENOM; CLU_079400_1_0_1; -.
DR   InParanoid; Q6NLQ3; -.
DR   OMA; DIHAMMV; -.
DR   OrthoDB; 1160303at2759; -.
DR   PhylomeDB; Q6NLQ3; -.
DR   PRO; PR:Q6NLQ3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q6NLQ3; baseline and differential.
DR   Genevisible; Q6NLQ3; AT.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR   GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR   GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR   GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR   Gene3D; 1.10.3520.10; -; 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   Pfam; PF08718; GLTP; 1.
DR   SUPFAM; SSF110004; SSF110004; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Reference proteome; Transport.
FT   CHAIN           1..223
FT                   /note="Glycolipid transfer protein 2"
FT                   /id="PRO_0000432645"
FT   BINDING         69
FT                   /ligand="ganglioside GM3 (d18:1(4E))"
FT                   /ligand_id="ChEBI:CHEBI:60065"
FT                   /evidence="ECO:0000305|PubMed:16309699"
FT   BINDING         73
FT                   /ligand="ganglioside GM3 (d18:1(4E))"
FT                   /ligand_id="ChEBI:CHEBI:60065"
FT                   /evidence="ECO:0000305|PubMed:16309699"
FT   BINDING         116
FT                   /ligand="ganglioside GM3 (d18:1(4E))"
FT                   /ligand_id="ChEBI:CHEBI:60065"
FT                   /evidence="ECO:0000305|PubMed:16309699"
FT   BINDING         155
FT                   /ligand="ganglioside GM3 (d18:1(4E))"
FT                   /ligand_id="ChEBI:CHEBI:60065"
FT                   /evidence="ECO:0000305|PubMed:16309699"
SQ   SEQUENCE   223 AA;  25705 MW;  DE9F831FDEF61F14 CRC64;
     MKRKRYEMEK KKKTEIQTAI EELSVFIVTK PADKTEATHI PLRPILSFCS LIIQVLDKIG
     PTMAVLRQDI DQNIQRLEKF YETDSCVYSN LAEILKKEKE EGTSKMVASC GRALFWLTRT
     MDFTAGLLRL LSKEMSSKME ELVEECYMTT LKPHHGWIAS AAFKVCLKLV PDNKTFMEAI
     GARDESYDTL REDIDTLSSL LTPILKEIYF VLEQYGLSRL RSM