GLTP3_ARATH
ID GLTP3_ARATH Reviewed; 233 AA.
AC Q9LU33; A0JPU4; Q0WRI8; Q8LCH8;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Glycolipid transfer protein 3 {ECO:0000303|PubMed:16309699};
GN Name=GLTP3 {ECO:0000303|PubMed:16309699};
GN OrderedLocusNames=At3g21260 {ECO:0000312|Araport:AT3G21260};
GN ORFNames=MXL8.12 {ECO:0000312|EMBL:BAB01718.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=16309699; DOI=10.1016/j.jmb.2005.10.031;
RA Airenne T.T., Kidron H., Nymalm Y., Nylund M., West G., Mattjus P.,
RA Salminen T.A.;
RT "Structural evidence for adaptive ligand binding of glycolipid transfer
RT protein.";
RL J. Mol. Biol. 355:224-236(2006).
CC -!- FUNCTION: May be involved in glycolipids transfer.
CC {ECO:0000305|PubMed:16309699}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9LU33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LU33-2; Sequence=VSP_057554;
CC Name=3;
CC IsoId=Q9LU33-3; Sequence=VSP_057553;
CC -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
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DR EMBL; AB023045; BAB01718.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76483.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76484.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76485.1; -; Genomic_DNA.
DR EMBL; AK228318; BAF00261.1; -; mRNA.
DR EMBL; BT029314; ABK32128.1; -; mRNA.
DR EMBL; AY086592; AAM63652.1; -; mRNA.
DR RefSeq; NP_001154632.1; NM_001161160.2. [Q9LU33-1]
DR RefSeq; NP_566679.1; NM_113021.3. [Q9LU33-3]
DR RefSeq; NP_850619.1; NM_180288.2. [Q9LU33-2]
DR AlphaFoldDB; Q9LU33; -.
DR SMR; Q9LU33; -.
DR STRING; 3702.AT3G21260.3; -.
DR PaxDb; Q9LU33; -.
DR PRIDE; Q9LU33; -.
DR EnsemblPlants; AT3G21260.1; AT3G21260.1; AT3G21260. [Q9LU33-3]
DR EnsemblPlants; AT3G21260.2; AT3G21260.2; AT3G21260. [Q9LU33-2]
DR EnsemblPlants; AT3G21260.3; AT3G21260.3; AT3G21260. [Q9LU33-1]
DR GeneID; 821680; -.
DR Gramene; AT3G21260.1; AT3G21260.1; AT3G21260. [Q9LU33-3]
DR Gramene; AT3G21260.2; AT3G21260.2; AT3G21260. [Q9LU33-2]
DR Gramene; AT3G21260.3; AT3G21260.3; AT3G21260. [Q9LU33-1]
DR KEGG; ath:AT3G21260; -.
DR Araport; AT3G21260; -.
DR TAIR; locus:2094736; AT3G21260.
DR eggNOG; KOG3221; Eukaryota.
DR HOGENOM; CLU_079400_1_0_1; -.
DR InParanoid; Q9LU33; -.
DR OMA; CILKVYN; -.
DR OrthoDB; 1160303at2759; -.
DR PhylomeDB; Q9LU33; -.
DR PRO; PR:Q9LU33; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LU33; baseline and differential.
DR Genevisible; Q9LU33; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR Gene3D; 1.10.3520.10; -; 1.
DR InterPro; IPR036497; GLTP_sf.
DR InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR Pfam; PF08718; GLTP; 1.
DR SUPFAM; SSF110004; SSF110004; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Lipid transport; Reference proteome; Transport.
FT CHAIN 1..233
FT /note="Glycolipid transfer protein 3"
FT /id="PRO_0000432646"
FT BINDING 79
FT /ligand="ganglioside GM3 (d18:1(4E))"
FT /ligand_id="ChEBI:CHEBI:60065"
FT /evidence="ECO:0000305|PubMed:16309699"
FT BINDING 83
FT /ligand="ganglioside GM3 (d18:1(4E))"
FT /ligand_id="ChEBI:CHEBI:60065"
FT /evidence="ECO:0000305|PubMed:16309699"
FT BINDING 126
FT /ligand="ganglioside GM3 (d18:1(4E))"
FT /ligand_id="ChEBI:CHEBI:60065"
FT /evidence="ECO:0000305|PubMed:16309699"
FT BINDING 165
FT /ligand="ganglioside GM3 (d18:1(4E))"
FT /ligand_id="ChEBI:CHEBI:60065"
FT /evidence="ECO:0000305|PubMed:16309699"
FT VAR_SEQ 1..89
FT /note="Missing (in isoform 3)"
FT /id="VSP_057553"
FT VAR_SEQ 1..85
FT /note="MKRKRCEMEETTKKKKMTEIGSAIEELSVLSIAKTTIVTTEKEAINIINLPL
FT KPLLSFCNIIVQVLDKIGPTMAVLRHDIDQNIQ -> M (in isoform 2)"
FT /id="VSP_057554"
FT CONFLICT 182
FT /note="N -> K (in Ref. 5; AAM63652)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 26517 MW; 9A795F53A6C96F51 CRC64;
MKRKRCEMEE TTKKKKMTEI GSAIEELSVL SIAKTTIVTT EKEAINIINL PLKPLLSFCN
IIVQVLDKIG PTMAVLRHDI DQNIQRLEKM WESDPLVYSN LVEILRKEAK EGSSRKPKSC
SRAALWLTRA MDFTLALLQR LVKDMSQNME QAIEECYNLT IKPWHGWISS AAFKVALKLV
PNNNTFINVL AAKDETHQMV QDDITSLISL LIPLLSQLHS ILELYEVSKL KSP
