ID   GLTP_PANTR              Reviewed;         209 AA.
AC   B0YN54; B0YL50;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Glycolipid transfer protein;
DE            Short=GLTP;
GN   Name=GLTP;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Skin fibroblast;
RX   PubMed=18261224; DOI=10.1186/1471-2164-9-72;
RA   Zou X., Chung T., Lin X., Malakhova M.L., Pike H.M., Brown R.E.;
RT   "Human glycolipid transfer protein (GLTP) genes: organization,
RT   transcriptional status and evolution.";
RL   BMC Genomics 9:72-72(2008).
CC   -!- FUNCTION: Accelerates the intermembrane transfer of various
CC       glycolipids. Catalyzes the transfer of various glycosphingolipids
CC       between membranes but does not catalyze the transfer of phospholipids.
CC       May be involved in the intracellular translocation of glucosylceramides
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
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DR   EMBL; EF520721; ABP94016.1; -; Genomic_DNA.
DR   EMBL; EF688398; ABV45189.1; -; mRNA.
DR   RefSeq; NP_001108230.1; NM_001114758.1.
DR   AlphaFoldDB; B0YN54; -.
DR   SMR; B0YN54; -.
DR   STRING; 9598.ENSPTRP00000060721; -.
DR   PaxDb; B0YN54; -.
DR   GeneID; 467126; -.
DR   KEGG; ptr:467126; -.
DR   CTD; 51228; -.
DR   eggNOG; KOG3221; Eukaryota.
DR   InParanoid; B0YN54; -.
DR   OrthoDB; 1160303at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR   GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR   GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR   GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR   Gene3D; 1.10.3520.10; -; 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   Pfam; PF08718; GLTP; 1.
DR   SUPFAM; SSF110004; SSF110004; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Lipid transport; Reference proteome; Repeat;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P68266"
FT   CHAIN           2..209
FT                   /note="Glycolipid transfer protein"
FT                   /id="PRO_0000343608"
FT   REPEAT          45..55
FT                   /note="1"
FT   REPEAT          56..66
FT                   /note="2"
FT   REGION          45..66
FT                   /note="2 X 12 AA approximate tandem repeats"
FT   BINDING         48..55
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   BINDING         140
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   BINDING         207
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P68266"
SQ   SEQUENCE   209 AA;  23850 MW;  F3DD96D702AE22CF CRC64;
     MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS GNITKIKAVY
     DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG LRFIQVFLQS ICDGERDENH
     PNLIRVNATK AYEMALKKYH GWIVQKIFQA ALYAAPYKSD FLKALSKGQN VTEEECLEKI
     RLFLVNYTAT IDVIYEMYTQ MNAELNYKV