ID   GLTP_PIG                Reviewed;         209 AA.
AC   P68266; P17403; Q9MYP3;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Glycolipid transfer protein;
DE            Short=GLTP;
GN   Name=GLTP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10671554; DOI=10.1074/jbc.275.7.5104;
RA   Lin X., Mattjus P., Pike H.M., Windebank A.J., Brown R.E.;
RT   "Cloning and expression of glycolipid transfer protein from bovine and
RT   porcine brain.";
RL   J. Biol. Chem. 275:5104-5110(2000).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-209, ACETYLATION AT ALA-2, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   TISSUE=Brain;
RX   PubMed=2190982; DOI=10.1016/s0021-9258(19)38716-2;
RA   Abe A.;
RT   "Primary structure of glycolipid transfer protein from pig brain.";
RL   J. Biol. Chem. 265:9634-9637(1990).
CC   -!- FUNCTION: Accelerates the intermembrane transfer of various
CC       glycolipids. Catalyzes the transfer of various glycosphingolipids
CC       between membranes but does not catalyze the transfer of phospholipids.
CC       May be involved in the intracellular translocation of glucosylceramides
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
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DR   EMBL; AF209702; AAF33208.1; -; mRNA.
DR   PIR; A36432; A36432.
DR   RefSeq; NP_998987.1; NM_213822.1.
DR   RefSeq; XP_013842375.1; XM_013986921.1.
DR   AlphaFoldDB; P68266; -.
DR   SMR; P68266; -.
DR   STRING; 9823.ENSSSCP00000010597; -.
DR   iPTMnet; P68266; -.
DR   PaxDb; P68266; -.
DR   PeptideAtlas; P68266; -.
DR   PRIDE; P68266; -.
DR   GeneID; 396765; -.
DR   CTD; 51228; -.
DR   eggNOG; KOG3221; Eukaryota.
DR   InParanoid; P68266; -.
DR   OrthoDB; 1160303at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR   GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IBA:GO_Central.
DR   GO; GO:0051861; F:glycolipid binding; ISS:UniProtKB.
DR   GO; GO:0008289; F:lipid binding; ISS:HGNC-UCL.
DR   GO; GO:0120013; F:lipid transfer activity; ISS:HGNC.
DR   GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR   GO; GO:0120009; P:intermembrane lipid transfer; ISS:HGNC.
DR   Gene3D; 1.10.3520.10; -; 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   Pfam; PF08718; GLTP; 1.
DR   SUPFAM; SSF110004; SSF110004; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Lipid transport;
KW   Reference proteome; Repeat; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2190982"
FT   CHAIN           2..209
FT                   /note="Glycolipid transfer protein"
FT                   /id="PRO_0000148917"
FT   REPEAT          45..55
FT                   /note="1"
FT   REPEAT          56..66
FT                   /note="2"
FT   REGION          45..66
FT                   /note="2 X 12 AA approximate tandem repeats"
FT   BINDING         48..55
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   BINDING         140
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   BINDING         207
FT                   /ligand="beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-
FT                   N-[(9Z)-octadecenoyl]-sphing-4-enine"
FT                   /ligand_id="ChEBI:CHEBI:131557"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:2190982"
FT   CONFLICT        10
FT                   /note="R -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        65
FT                   /note="T -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="R -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   209 AA;  23922 MW;  1C4E2F9CD77DD714 CRC64;
     MALLAEHLLR PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS GNITKIKAVY
     DTNPTKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG LRFIQVFLQS ICDGERDENH
     PNLIRVNATK AYEMALKKYH GWIVQKIFQA ALYAAPYKSD FLKALSKGQN VTEEECLEKV
     RLFLVNYTAT IDVIYEMYTR MNAELNYKV