GLTR1_MYCTA
ID GLTR1_MYCTA Reviewed; 256 AA.
AC A5U6W5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=PGL/p-HBAD biosynthesis glycosyltransferase MRA_2984;
DE EC=2.4.1.-;
GN OrderedLocusNames=MRA_2984;
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra;
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- FUNCTION: Involved in glycosylation steps downstream of mono-O-methyl-
CC glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-
CC rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-
CC hydroxybenzoic acid derivatives (p-HBAD) and glycosylated
CC phenolphthiocerol dimycocerosates (PGL) biosynthesis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABQ74765.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000611; ABQ74765.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; A5U6W5; -.
DR SMR; A5U6W5; -.
DR STRING; 419947.MRA_2984; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR EnsemblBacteria; ABQ74765; ABQ74765; MRA_2984.
DR KEGG; mra:MRA_2984; -.
DR eggNOG; COG0463; Bacteria.
DR HOGENOM; CLU_025996_21_1_11; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Transferase.
FT CHAIN 1..256
FT /note="PGL/p-HBAD biosynthesis glycosyltransferase
FT MRA_2984"
FT /id="PRO_0000314433"
SQ SEQUENCE 256 AA; 29013 MW; 90C6EC628C59CA57 CRC64;
MAAPMFSIII PTLNVAAVLP ACLDSIARQT CGDFELVLVD GGSTDETLDI ANIFAPNLGE
RLIIHRDTDQ GVYDAMNRGV DLATGTWLLF LGADDSLYEA DTLARVAAFI GEHEPSDLVY
GDVIMRSTNF RWGGAFDLDR LLFKRNICHQ AIFYRRGLFG TIGPYNLRYR VLADWDFNIR
CFSNPALVTR YMHVVVASYN EFGGLSNTIV DKEFLKRLPM STRLGIRLVI VLVRRWPKVI
SRAMVMRTVI SWRRRR