ID   GLTR2_MYCBP             Reviewed;         366 AA.
AC   A1KMV2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Inactive PGL/p-HBAD biosynthesis glycosyltransferase BCG_2979c;
GN   OrderedLocusNames=BCG_2979c;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
RN   [2]
RP   LACK OF ACTIVITY.
RX   PubMed=15292272; DOI=10.1074/jbc.m406246200;
RA   Perez E., Constant P., Lemassu A., Laval F., Daffe M., Guilhot C.;
RT   "Characterization of three glycosyltransferases involved in the
RT   biosynthesis of the phenolic glycolipid antigens from the Mycobacterium
RT   tuberculosis complex.";
RL   J. Biol. Chem. 279:42574-42583(2004).
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: This sequence is shorter than orthologs and has a completely
CC       different amino acid sequence after position 289 due to a single
CC       nucleotide insertion. This protein is not functional which could
CC       partially explain the failure of M.bovis derivatives to produce the
CC       full-length PGL. {ECO:0000305}.
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DR   EMBL; AM408590; CAL72968.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1KMV2; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   KEGG; mbb:BCG_2979c; -.
DR   HOGENOM; CLU_064476_0_0_11; -.
DR   OMA; THTEREY; -.
DR   Proteomes; UP000001472; Chromosome.
PE   3: Inferred from homology;
FT   CHAIN           1..366
FT                   /note="Inactive PGL/p-HBAD biosynthesis glycosyltransferase
FT                   BCG_2979c"
FT                   /id="PRO_0000314435"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..315
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  40668 MW;  3928F758736542C1 CRC64;
     MEETSVAGDP GPDAGTSTAP NAAPEPVARR QRILFVGEAA TLAHVVRPFV LARSLDPSRY
     EVHFACDPRF NKLLGPLPFP HHPIHTVPSE EVLLKIAQGR LFYNTRTLRK YIAADRKILN
     EIAPDVVVGD NRLSLSVSAR LAGIPYIAIA NAYWSPQARR RFPLPDVPWT RFFGVRPVSI
     LYRLYRPLIF ALYCLPLNWL RRKHGLSSLG WDLCRIFTDG DYTLYADVPE LVPTYNLPAN
     HRYLGPVLWS PDVKPPTWWH SLPTDRPIIY ATLGSSGGKN LLQVVLNALG RFTRDGDRGH
     RWPEPPEERA GQRLRRGLPA GRSGCSALRR GALQRRQPDD AAGVGGRGAG DRAPQQHGPA
     LEHGGP