ID   GLTR2_MYCTA             Reviewed;         428 AA.
AC   A5U6W6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=PGL/p-HBAD biosynthesis glycosyltransferase MRA_2985;
DE            EC=2.4.1.-;
GN   OrderedLocusNames=MRA_2985;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Involved in glycosylation steps downstream of mono-O-methyl-
CC       glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-
CC       rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-
CC       hydroxybenzoic acid derivatives (p-HBAD) and glycosylated
CC       phenolphthiocerol dimycocerosates (PGL) biosynthesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000611; ABQ74766.1; -; Genomic_DNA.
DR   RefSeq; WP_003899557.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U6W6; -.
DR   SMR; A5U6W6; -.
DR   STRING; 419947.MRA_2985; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   EnsemblBacteria; ABQ74766; ABQ74766; MRA_2985.
DR   GeneID; 45426946; -.
DR   KEGG; mra:MRA_2985; -.
DR   eggNOG; COG1819; Bacteria.
DR   HOGENOM; CLU_692271_0_0_11; -.
DR   OMA; THTEREY; -.
DR   OrthoDB; 1485440at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProt.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   Pfam; PF00201; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..428
FT                   /note="PGL/p-HBAD biosynthesis glycosyltransferase
FT                   MRA_2985"
FT                   /id="PRO_0000314437"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  46796 MW;  9AED70A49571BEF2 CRC64;
     MEETSVAGDP GPDAGTSTAP NAAPEPVARR QRILFVGEAA TLAHVVRPFV LARSLDPSRY
     EVHFACDPRF NKLLGPLPFP HHPIHTVPSE EVLLKIAQGR LFYNTRTLRK YIAADRKILN
     EIAPDVVVGD NRLSLSVSAR LAGIPYIAIA NAYWSPQARR RFPLPDVPWT RFFGVRPVSI
     LYRLYRPLIF ALYCLPLNWL RRKHGLSSLG WDLCRIFTDG DYTLYADVPE LVPTYNLPAN
     HRYLGPVLWS PDVKPPTWWH SLPTDRPIIY ATLGSSGGKN LLQVVLNALA DLPVTVIAAT
     AGRNHLKNVP ANAFVADYLP GEAAAARSAV VLCNGGSPTT QQALAAGVPV IGLPSNMDQH
     LNMEALERAG AGVLLRTERL NTEGVAAAVK QVLSGAEFRQ AARRLAEAFG PDFAGFPQHI
     ESALRLVC