ID   GLTS_HAEIN              Reviewed;         404 AA.
AC   P45240;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Sodium/glutamate symporter {ECO:0000255|HAMAP-Rule:MF_02062};
GN   Name=gltS {ECO:0000255|HAMAP-Rule:MF_02062}; OrderedLocusNames=HI_1530;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Catalyzes the sodium-dependent transport of glutamate.
CC       {ECO:0000255|HAMAP-Rule:MF_02062}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02062}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02062}.
CC   -!- SIMILARITY: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27)
CC       family. {ECO:0000255|HAMAP-Rule:MF_02062}.
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DR   EMBL; L42023; AAC23176.1; -; Genomic_DNA.
DR   PIR; G64127; G64127.
DR   RefSeq; NP_439679.1; NC_000907.1.
DR   RefSeq; WP_005693557.1; NC_000907.1.
DR   AlphaFoldDB; P45240; -.
DR   STRING; 71421.HI_1530; -.
DR   PRIDE; P45240; -.
DR   EnsemblBacteria; AAC23176; AAC23176; HI_1530.
DR   KEGG; hin:HI_1530; -.
DR   PATRIC; fig|71421.8.peg.1601; -.
DR   eggNOG; COG0786; Bacteria.
DR   HOGENOM; CLU_040907_0_0_6; -.
DR   OMA; PTAMVNM; -.
DR   PhylomeDB; P45240; -.
DR   BioCyc; HINF71421:G1GJ1-1552-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015501; F:glutamate:sodium symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015813; P:L-glutamate transmembrane transport; IEA:InterPro.
DR   HAMAP; MF_02062; GltS; 1.
DR   InterPro; IPR004445; GltS.
DR   PANTHER; PTHR36178; PTHR36178; 1.
DR   Pfam; PF03616; Glt_symporter; 1.
DR   TIGRFAMs; TIGR00210; gltS; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Ion transport;
KW   Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..404
FT                   /note="Sodium/glutamate symporter"
FT                   /id="PRO_0000052334"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
SQ   SEQUENCE   404 AA;  43371 MW;  8930C6BD39BDAC3C CRC64;
     MSYTFSTYET LALASLVLLL GYFLVKRINV LKTFNIPEPV VGGFIVAIGL LIWHKIDGTS
     FNFDKNLQTT MMLVFFTSIG LSANFSRLIK GGKPLVVFLF IAALLIFGQN VIGIASSMAL
     GIHPAYGLLA GSVTLTGGHG TGAAWADTFA HQFNLQGATE IAIACATFGL VFGGIIGGPV
     ARFLLNRQKQ GENPENDEVD DIQEAFEHPT YKRKITARSL IETIAMISVC LLIGQYLDVQ
     TKGTALQLPT FVWCLFTGVI VRNILTNIFR FQVAESAIDV LGSVGLSIFL AIALMSLRLW
     ELAGLAIDVL IVLAIQVAFM AAFAIFITYR AMGKDYDAVV LSAGHCGFGL GATPTAIANM
     QAVTSRFGPS HKAFLIVPMV GAFFIDLINA ALLKVSFAVV NILA