ID   GLTS_SHIFL              Reviewed;         401 AA.
AC   P0AER9; P19933;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Sodium/glutamate symporter {ECO:0000255|HAMAP-Rule:MF_02062};
GN   Name=gltS {ECO:0000255|HAMAP-Rule:MF_02062};
GN   OrderedLocusNames=SF3693, S4076;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Catalyzes the sodium-dependent transport of glutamate.
CC       {ECO:0000255|HAMAP-Rule:MF_02062}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02062}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02062}.
CC   -!- SIMILARITY: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27)
CC       family. {ECO:0000255|HAMAP-Rule:MF_02062}.
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DR   EMBL; AE005674; AAN45140.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP19053.1; -; Genomic_DNA.
DR   RefSeq; NP_709433.1; NC_004337.2.
DR   RefSeq; WP_000468833.1; NZ_WPGW01000042.1.
DR   AlphaFoldDB; P0AER9; -.
DR   STRING; 198214.SF3693; -.
DR   EnsemblBacteria; AAN45140; AAN45140; SF3693.
DR   EnsemblBacteria; AAP19053; AAP19053; S4076.
DR   GeneID; 1026189; -.
DR   GeneID; 58389951; -.
DR   KEGG; sfl:SF3693; -.
DR   KEGG; sfx:S4076; -.
DR   PATRIC; fig|198214.7.peg.4357; -.
DR   HOGENOM; CLU_040907_0_0_6; -.
DR   OMA; PTAMVNM; -.
DR   OrthoDB; 1284248at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015501; F:glutamate:sodium symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015813; P:L-glutamate transmembrane transport; IEA:InterPro.
DR   HAMAP; MF_02062; GltS; 1.
DR   InterPro; IPR004445; GltS.
DR   PANTHER; PTHR36178; PTHR36178; 1.
DR   Pfam; PF03616; Glt_symporter; 1.
DR   TIGRFAMs; TIGR00210; gltS; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Ion transport;
KW   Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..401
FT                   /note="Sodium/glutamate symporter"
FT                   /id="PRO_0000052333"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02062"
SQ   SEQUENCE   401 AA;  42425 MW;  9569AE0AF75634EC CRC64;
     MFHLDTLATL VAATLTLLLG RKLVHSVSFL KKYTIPEPVA GGLLVALALL VLKKSMGWEV
     NFDMSLRDPL MLAFFATIGL NANIASLRAG GRVVGIFLIV VVGLLVMQNA IGIGMASLLG
     LDPLMGLLAG SITLSGGHGT GAAWSKLFIE RYGFTNATEV AMACATFGLV LGGLIGGPVA
     RYLVKHSTTP NGIPDDQEVP TAFEKPDVGR MITSLVLIET IALIAICLTV GKIVAQLLAG
     TAFELPTFVC VLFVGVILSN GLSIMGFYRV FERAVSVLGN VSLSLFLAMA LMGLKLWELA
     SLALPMLAIL VVQTIFMALY AIFVTWRMMG KNYDAAVLAA GHCGFGLGAT PTAIANMQAI
     TERFGPSHMA FLVVPMVGAF FIDIVNALVI KLYLMLPIFA G