GLTS_SYNY3
ID GLTS_SYNY3 Reviewed; 1556 AA.
AC P55038; Q59980;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Ferredoxin-dependent glutamate synthase 2;
DE EC=1.4.7.1;
DE AltName: Full=FD-GOGAT;
GN Name=gltS; OrderedLocusNames=sll1499;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7727752; DOI=10.1007/bf00020228;
RA Navarro F., Chavez S., Candau P., Florencio F.J.;
RT "Existence of two ferredoxin-glutamate synthases in the cyanobacterium
RT Synechocystis sp. PCC 6803. Isolation and insertional inactivation of gltB
RT and gltS genes.";
RL Plant Mol. Biol. 27:753-767(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Terauchi K., Ikeuchi M., Ohmori M.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-
CC oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-
CC [ferredoxin]; Xref=Rhea:RHEA:12128, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC COMP:10001, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:58359; EC=1.4.7.1;
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Note=Binds 1 [3Fe-4S] cluster.;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC -!- PATHWAY: Amino-acid biosynthesis; L-glutamate biosynthesis via GLT
CC pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin
CC route): step 1/1.
CC -!- PATHWAY: Energy metabolism; nitrogen metabolism.
CC -!- SIMILARITY: Belongs to the glutamate synthase family. {ECO:0000305}.
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DR EMBL; X92480; CAA63218.1; -; Genomic_DNA.
DR EMBL; D78371; BAA11379.1; -; Genomic_DNA.
DR EMBL; BA000022; BAA18693.1; -; Genomic_DNA.
DR PIR; S76781; S76781.
DR PDB; 1LLW; X-ray; 2.70 A; A=37-1556.
DR PDB; 1LLZ; X-ray; 3.00 A; A=37-1556.
DR PDB; 1LM1; X-ray; 2.80 A; A=37-1556.
DR PDB; 1OFD; X-ray; 2.00 A; A/B=37-1556.
DR PDB; 1OFE; X-ray; 2.45 A; A/B=37-1556.
DR PDBsum; 1LLW; -.
DR PDBsum; 1LLZ; -.
DR PDBsum; 1LM1; -.
DR PDBsum; 1OFD; -.
DR PDBsum; 1OFE; -.
DR AlphaFoldDB; P55038; -.
DR SASBDB; P55038; -.
DR SMR; P55038; -.
DR IntAct; P55038; 4.
DR STRING; 1148.1653782; -.
DR DrugBank; DB03247; Flavin mononucleotide.
DR MEROPS; C44.003; -.
DR PaxDb; P55038; -.
DR PRIDE; P55038; -.
DR EnsemblBacteria; BAA18693; BAA18693; BAA18693.
DR KEGG; syn:sll1499; -.
DR eggNOG; COG0067; Bacteria.
DR eggNOG; COG0069; Bacteria.
DR eggNOG; COG0070; Bacteria.
DR InParanoid; P55038; -.
DR OMA; LKTGWDV; -.
DR PhylomeDB; P55038; -.
DR BioCyc; MetaCyc:SGL_RS17380-MON; -.
DR BRENDA; 1.4.7.1; 382.
DR UniPathway; UPA00045; -.
DR UniPathway; UPA00634; UER00691.
DR EvolutionaryTrace; P55038; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016041; F:glutamate synthase (ferredoxin) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0097054; P:L-glutamate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00982; gltB_C; 1.
DR CDD; cd02808; GltS_FMN; 1.
DR Gene3D; 2.160.20.60; -; 1.
DR Gene3D; 3.20.20.70; -; 2.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR002489; Glu_synth_asu_C.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR InterPro; IPR006982; Glu_synth_centr_N.
DR InterPro; IPR002932; Glu_synthdom.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR Pfam; PF00310; GATase_2; 1.
DR Pfam; PF04898; Glu_syn_central; 1.
DR Pfam; PF01645; Glu_synthase; 1.
DR Pfam; PF01493; GXGXG; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR SUPFAM; SSF69336; SSF69336; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; 3Fe-4S; Amino-acid biosynthesis; FAD; Flavoprotein; FMN;
KW Glutamate biosynthesis; Glutamine amidotransferase; Iron; Iron-sulfur;
KW Metal-binding; Oxidoreductase; Reference proteome.
FT CHAIN 1..1556
FT /note="Ferredoxin-dependent glutamate synthase 2"
FT /id="PRO_0000170794"
FT DOMAIN 37..431
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
FT REGION 1533..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 37
FT /note="For GATase activity"
FT /evidence="ECO:0000250"
FT BINDING 1173
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 1179
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 1184
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT CONFLICT 491
FT /note="E -> Q (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 570..572
FT /note="ESA -> NPR (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 642..650
FT /note="GAILTENQS -> RRNIGLRIKV (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 659
FT /note="G -> E (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 940..941
FT /note="GG -> PP (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 1059
FT /note="H -> L (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 1295
FT /note="E -> RK (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 1310
FT /note="V -> D (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 1323
FT /note="A -> S (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT CONFLICT 1531
FT /note="Missing (in Ref. 1; CAA63218)"
FT /evidence="ECO:0000305"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 52..63
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 64..67
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 74..78
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 80..85
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 109..115
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 119..135
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 139..145
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 155..160
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 163..170
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 177..191
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 192..194
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 199..215
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 217..219
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 220..223
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 225..228
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 234..241
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 245..247
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 251..253
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 254..256
FT /evidence="ECO:0007829|PDB:1LLW"
FT STRAND 258..264
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 269..279
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 280..282
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 290..296
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 306..319
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 324..331
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 340..342
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 346..355
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 356..358
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 364..371
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 373..380
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 389..393
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 398..403
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 411..413
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 414..419
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 425..429
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 430..433
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 434..436
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 438..446
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 451..458
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 459..462
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 476..485
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 490..495
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 497..503
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 518..520
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 527..530
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 531..533
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 538..540
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 545..548
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 549..551
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 556..559
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 564..566
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 569..572
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 574..578
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 584..592
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 593..595
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 597..601
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 603..605
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 607..609
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 612..628
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 632..639
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 640..642
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 646..648
FT /evidence="ECO:0007829|PDB:1LLW"
FT STRAND 649..651
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 654..667
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 671..673
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 675..679
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 686..694
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 698..701
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 703..713
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 716..722
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 723..725
FT /evidence="ECO:0007829|PDB:1LLW"
FT HELIX 732..753
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 759..763
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 768..773
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 775..781
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 794..808
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 809..811
FT /evidence="ECO:0007829|PDB:1LLW"
FT STRAND 820..823
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 826..828
FT /evidence="ECO:0007829|PDB:1OFE"
FT HELIX 835..847
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 862..871
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 878..881
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 882..884
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 893..895
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 899..903
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 913..915
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 918..931
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 944..947
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 960..962
FT /evidence="ECO:0007829|PDB:1LLW"
FT STRAND 977..981
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 990..995
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 997..1002
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1017..1019
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1022..1028
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1048..1061
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1065..1072
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1077..1086
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1090..1095
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1102..1105
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1106..1111
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1116..1129
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1133..1135
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1137..1143
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1147..1155
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1159..1162
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1165..1170
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1179..1181
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1187..1189
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1193..1196
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1203..1224
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1229..1232
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1236..1238
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1239..1241
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1248..1251
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1256..1259
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1269..1271
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1283..1289
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1291..1299
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1302..1309
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1318..1328
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1329..1331
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1336..1345
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1347..1352
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1357..1365
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1369..1372
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1375..1381
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1390..1392
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1400..1403
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1408..1414
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1419..1422
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1427..1431
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1437..1440
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1442..1448
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1454..1456
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1457..1459
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1462..1468
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1470..1472
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1474..1477
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1480..1482
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1484..1486
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1491..1508
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1511..1518
FT /evidence="ECO:0007829|PDB:1OFD"
FT HELIX 1520..1524
FT /evidence="ECO:0007829|PDB:1OFD"
FT STRAND 1527..1531
FT /evidence="ECO:0007829|PDB:1OFD"
FT TURN 1533..1537
FT /evidence="ECO:0007829|PDB:1LM1"
FT TURN 1539..1541
FT /evidence="ECO:0007829|PDB:1OFD"
SQ SEQUENCE 1556 AA; 169499 MW; 4BDAD5F9A4064D9D CRC64;
MSFQYPLLAP MTNSSVATNS NQPFLGQPWL VEERDACGVG FIANLRGKPD HTLVEQALKA
LGCMEHRGGC SADNDSGDGA GVMTAIPREL LAQWFNTRNL PMPDGDRLGV GMVFLPQEPS
AREVARAYVE EVVRLEKLTV LGWREVPVNS DVLGIQAKNN QPHIEQILVT CPEGCAGDEL
DRRLYIARSI IGKKLAEDFY VCSFSCRTIV YKGMVRSIIL GEFYLDLKNP GYTSNFAVYH
RRFSTNTMPK WPLAQPMRLL GHNGEINTLL GNINWMAARE KELEVSGWTK AELEALTPIV
NQANSDSYNL DSALELLVRT GRSPLEAAMI LVPEAYKNQP ALKDYPEISD FHDYYSGLQE
PWDGPALLVF SDGKIVGAGL DRNGLRPARY CITKDDYIVL GSEAGVVDLP EVDIVEKGRL
APGQMIAVDL AEQKILKNYQ IKQQAAQKYP YGEWIKIQRQ TVASDSFAEK TLFNDAQTVL
QQQAAFGYTA EDVEMVVVPM ASQGKEPTFC MGDDTPLAVL SHKPRLLYDY FKQRFAQVTN
PPIDPLRENL VMSLAMFLGK RGNLLEPKAE SARTIKLRSP LVNEVELQAI KTGQLQVAEV
STLYDLDGVN SLETALDNLV KTAIATVQAG AEILVLTDRP NGAILTENQS FIPPLLAVGA
VHHHLIRAGL RLKASLIVDT AQCWSTHHFA CLVGYGASAI CPYLALESVR QWWLDEKTQK
LMENGRLDRI DLPTALKNYR QSVEAGLFKI LSKMGISLLA SYHGAQIFEA IGLGAELVEY
AFAGTTSRVG GLTIADVAGE VMVFHGMAFP EMAKKLENFG FVNYRPGGEY HMNSPEMSKS
LHKAVAAYKV GGNGNNGEAY DHYELYRQYL KDRPVTALRD LLDFNADQPA ISLEEVESVE
SIVKRFCTGG MSLGALSREA HETLAIAMNR LGAKSNSGEG GEDVVRYLTL DDVDSEGNSP
TLPHLHGLQN GDTANSAIKQ IASGRFGVTP EYLMSGKQLE IKMAQGAKPG EGGQLPGKKV
SEYIAMLRRS KPGVTLISPP PHHDIYSIED LAQLIYDLHQ INPEAQVSVK LVAEIGIGTI
AAGVAKANAD IIQISGHDGG TGASPLSSIK HAGSPWELGV TEVHRVLMEN QLRDRVLLRA
DGGLKTGWDV VMAALMGAEE YGFGSIAMIA EGCIMARVCH TNNCPVGVAT QQERLRQRFK
GVPGQVVNFF YFIAEEVRSL LAHLGYRSLD DIIGRTDLLK VRSDVQLSKT QNLTLDCLLN
LPDTKQNRQW LNHEPVHSNG PVLDDDILAD PDIQEAINHQ TTATKTYRLV NTDRTVGTRL
SGAIAKKYGN NGFEGNITLN FQGAAGQSFG AFNLDGMTLH LQGEANDYVG KGMNGGEIVI
VPHPQASFAP EDNVIIGNTC LYGATGGNLY ANGRAGERFA VRNSVGKAVI EGAGDHCCEY
MTGGVIVVLG PVGRNVGAGM TGGLAYFLDE VGDLPEKINP EIITLQRITA SKGEEQLKSL
ITAHVEHTGS PKGKAILANW SDYLGKFWQA VPPSEKDSPE ANGDVSLTGE KTLTSV
