ID   GLUC1_ONCKI             Reviewed;          68 AA.
AC   P07449;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Glucagon-1;
DE   Contains:
DE     RecName: Full=Glucagon-1;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 1-1;
DE   Flags: Precursor; Fragment;
GN   Name=gcg;
OS   Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8019;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3520699; DOI=10.1016/0167-0115(86)90205-3;
RA   Plisetskaya E., Pollock H.G., Rouse J.B., Hamilton J.W., Kimmel J.R.,
RA   Gorbman A.;
RT   "Isolation and structures of coho salmon (Oncorhynchus kisutch) glucagon
RT   and glucagon-like peptide.";
RL   Regul. Pept. 14:57-67(1986).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with
CC       American goosefish sequences.
CC   -!- MISCELLANEOUS: Gln-14 is a unique substitution from leucine in other
CC       known glucagon sequences and glucagon-like peptides.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; JP0103; GCONC.
DR   Proteomes; UP000694557; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon-1"
FT                   /id="PRO_0000011355"
FT   PEPTIDE         38..68
FT                   /note="Glucagon-like peptide 1-1"
FT                   /id="PRO_0000011356"
FT   NON_TER         1
FT   NON_TER         68
SQ   SEQUENCE   68 AA;  7819 MW;  50D14214FF204C04 CRC64;
     HSEGTFSNDY SKYQEERMAQ DFVQWLMNSX XXXXXXXHAD GTYTSNVSTY LQDQAAKDFV
     SWLKSGRA