ID   GLUC1_ORENI             Reviewed;          36 AA.
AC   P81026;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Glucagon-1;
DE   AltName: Full=Glucagon I;
GN   Name=gcg1;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7656183; DOI=10.1016/0742-8413(95)00023-z;
RA   Nguyen T.M., Wright J.R. Jr., Nielsen P.F., Conlon J.M.;
RT   "Characterization of the pancreatic hormones from the Brockmann body of the
RT   tilapia: implications for islet xenograft studies.";
RL   Comp. Biochem. Physiol. 111C:33-44(1995).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P81026; -.
DR   SMR; P81026; -.
DR   STRING; 8128.ENSONIP00000023051; -.
DR   eggNOG; ENOG502RYPR; Eukaryota.
DR   HOGENOM; CLU_090687_2_0_1; -.
DR   InParanoid; P81026; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Glucagon-1"
FT                   /id="PRO_0000044742"
SQ   SEQUENCE   36 AA;  4252 MW;  5AAFBF0254425756 CRC64;
     HSEGTFSNDY SKYLEDRKAQ DFVRWLMNNK RSGAAE