GLUC1_PETMA
ID GLUC1_PETMA Reviewed; 160 AA.
AC Q9PUR1; Q9PRZ7; Q9PRZ8;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Glucagon-1;
DE Contains:
DE RecName: Full=Glucagon-1;
DE AltName: Full=Glucagon I;
DE Contains:
DE RecName: Full=Glucagon-like peptide 1-I;
DE Short=GLP-1I;
DE Contains:
DE RecName: Full=Glucagon-like peptide 2-I;
DE Short=GLP-2I;
DE Flags: Precursor;
GN Name=gcg1;
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=10555286; DOI=10.1093/oxfordjournals.molbev.a026067;
RA Irwin D.M., Huner O., Youson J.H.;
RT "Lamprey proglucagon and the origin of glucagon-like peptides.";
RL Mol. Biol. Evol. 16:1548-1557(1999).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 43-71 AND 82-113.
RC TISSUE=Intestine;
RX PubMed=8405897; DOI=10.1006/gcen.1993.1109;
RA Conlon J.M., Nielsen P.F., Youson J.H.;
RT "Primary structures of glucagon and glucagon-like peptide isolated from the
RT intestine of the parasitic phase lamprey Petromyzon marinus.";
RL Gen. Comp. Endocrinol. 91:96-104(1993).
CC -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC blood sugar level.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; AF159707; AAF09186.1; -; mRNA.
DR AlphaFoldDB; Q9PUR1; -.
DR SMR; Q9PUR1; -.
DR STRING; 7757.ENSPMAP00000002387; -.
DR PRIDE; Q9PUR1; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; PTHR11418; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000305"
FT PROPEP 23..40
FT /evidence="ECO:0000250"
FT /id="PRO_0000011371"
FT PEPTIDE 43..71
FT /note="Glucagon-1"
FT /id="PRO_0000011372"
FT PROPEP 74..79
FT /evidence="ECO:0000250"
FT /id="PRO_0000011373"
FT PEPTIDE 82..113
FT /note="Glucagon-like peptide 1-I"
FT /id="PRO_0000011374"
FT PROPEP 116..127
FT /evidence="ECO:0000250"
FT /id="PRO_0000011375"
FT PEPTIDE 130..160
FT /note="Glucagon-like peptide 2-I"
FT /evidence="ECO:0000250"
FT /id="PRO_0000011376"
FT REGION 112..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18042 MW; 9A52C530D5A74072 CRC64;
MSDPGFLAAP VLLLLLVSLA SASLEQAASR DDDSAERPLS KRHSEGTFTS DYSKYLENKQ
AKDFVRWLMN AKRGGSELQR RHADGTFTND MTSYLDAKAA RDFVSWLARS DKSRRDGGDH
LAENSEDKRH AEDVNALLDR TMAKTFIEWL EKQNSNDQTD
