ID   GLUC1_XENLA             Reviewed;         266 AA.
AC   O42143;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Glucagon-1;
DE   AltName: Full=Glucagon I;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 1A;
DE              Short=GLP-1A;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 1B;
DE              Short=GLP-1B;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 1C;
DE              Short=GLP-1C;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 2;
DE              Short=GLP-2;
DE   Flags: Precursor;
GN   Name=gcg1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RC   TISSUE=Pancreas;
RX   PubMed=9223287; DOI=10.1073/pnas.94.15.7915;
RA   Irwin D.M., Satkunarajah M., Wen Y., Brubaker P.L., Pederson R.A.,
RA   Wheeler M.B.;
RT   "The Xenopus proglucagon gene encodes novel GLP-1-like peptides with
RT   insulinotropic properties.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:7915-7920(1997).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O42143-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O42143-2; Sequence=VSP_001755;
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; AF004432; AAB65660.1; -; mRNA.
DR   RefSeq; NP_001079142.1; NM_001085673.1. [O42143-1]
DR   AlphaFoldDB; O42143; -.
DR   SMR; O42143; -.
DR   GeneID; 373686; -.
DR   KEGG; xla:373686; -.
DR   CTD; 373686; -.
DR   Xenbase; XB-GENE-1000161; gcg.L.
DR   OrthoDB; 1349644at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 373686; Expressed in pancreas and 6 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 3.
DR   Pfam; PF00123; Hormone_2; 5.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 5.
DR   PROSITE; PS00260; GLUCAGON; 5.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cleavage on pair of basic residues; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..50
FT                   /id="PRO_0000011390"
FT   PEPTIDE         53..81
FT                   /note="Glucagon"
FT                   /id="PRO_0000011391"
FT   PROPEP          84..95
FT                   /id="PRO_0000011392"
FT   PEPTIDE         97..133
FT                   /note="Glucagon-like peptide 1A"
FT                   /id="PRO_0000011393"
FT   PROPEP          136..140
FT                   /id="PRO_0000011394"
FT   PEPTIDE         142..172
FT                   /note="Glucagon-like peptide 1B"
FT                   /id="PRO_0000011395"
FT   PROPEP          175..178
FT                   /id="PRO_0000011396"
FT   PEPTIDE         180..210
FT                   /note="Glucagon-like peptide 1C"
FT                   /id="PRO_0000011397"
FT   PROPEP          213..224
FT                   /id="PRO_0000011398"
FT   PEPTIDE         227..259
FT                   /note="Glucagon-like peptide 2"
FT                   /id="PRO_0000011399"
FT   PROPEP          261..266
FT                   /id="PRO_0000011400"
FT   REGION          23..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         214..261
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_001755"
SQ   SEQUENCE   266 AA;  30951 MW;  544F7BBC20AF872C CRC64;
     MKSTCYMIGI LLMILQNTYQ SPVPETDANS RSVKAARNEA VDDSEQLKEV KRHSQGTFTS
     DYSKYLDSRR AQDFVQWLMN TKRSGELSRR NADYERHAEG TFTSDVTQQL DEKAAKEFID
     WLINGGPSKE IISRRNAEFE RHAEGTYTND VTEYLEEKAA KEFIEWLIKG KPKKIRYSRH
     AEGTFTNDMT NYLEEKAAKE FVGWLIKGRP KRNFSEVHSV EEMDRRHADG SFTNDINKVL
     DIIAAQEFLD WVINTQETER DLLEEQ