GLUC2_ONCMY
ID GLUC2_ONCMY Reviewed; 178 AA.
AC Q91189; Q92168;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Glucagon-2;
DE AltName: Full=Glucagon II;
DE Contains:
DE RecName: Full=Glicentin-related polypeptide 2;
DE Short=GRPP 2;
DE Contains:
DE RecName: Full=Glucagon-2;
DE Contains:
DE RecName: Full=Glucagon-like peptide 1-2;
DE Short=GLP 1-2;
DE Contains:
DE RecName: Full=Glucagon-like peptide 2;
DE Short=GLP 2;
DE Flags: Precursor;
GN Name=gcg2;
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
RC TISSUE=Distal small intestine, and Pancreas;
RX PubMed=7776976; DOI=10.1210/mend.9.3.7776976;
RA Irwin D.M., Wong J.;
RT "Trout and chicken proglucagon: alternative splicing generates mRNA
RT transcripts encoding glucagon-like peptide 2.";
RL Mol. Endocrinol. 9:267-277(1995).
CC -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC blood sugar level. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Intestinal;
CC IsoId=Q91189-1; Sequence=Displayed;
CC Name=Pancreatic;
CC IsoId=Q91189-2; Sequence=VSP_050471;
CC -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC response to a drop in blood sugar concentration.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U19914; AAC59668.1; -; mRNA.
DR EMBL; U19916; AAC60210.1; -; Genomic_DNA.
DR EMBL; U19915; AAC60210.1; JOINED; Genomic_DNA.
DR EMBL; U19915; AAC60209.1; -; Genomic_DNA.
DR PIR; I51057; I51057.
DR RefSeq; NP_001118172.1; NM_001124700.1. [Q91189-1]
DR AlphaFoldDB; Q91189; -.
DR SMR; Q91189; -.
DR GeneID; 100136748; -.
DR KEGG; omy:100136748; -.
DR CTD; 100136748; -.
DR OrthoDB; 1349644at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR11418; PTHR11418; 1.
DR Pfam; PF00123; Hormone_2; 3.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cleavage on pair of basic residues; Hormone;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PEPTIDE 22..49
FT /note="Glicentin-related polypeptide 2"
FT /id="PRO_0000011364"
FT PEPTIDE 52..80
FT /note="Glucagon-2"
FT /id="PRO_0000011365"
FT PROPEP 83..87
FT /id="PRO_0000011366"
FT PEPTIDE 90..120
FT /note="Glucagon-like peptide 1-2"
FT /id="PRO_0000011367"
FT PROPEP 123..134
FT /id="PRO_0000011368"
FT PEPTIDE 137..169
FT /note="Glucagon-like peptide 2"
FT /id="PRO_0000011369"
FT PROPEP 171..178
FT /id="PRO_0000011370"
FT VAR_SEQ 124..178
FT /note="Missing (in isoform Pancreatic)"
FT /evidence="ECO:0000305"
FT /id="VSP_050471"
SQ SEQUENCE 178 AA; 19998 MW; E89D73866CD91C66 CRC64;
MFGIHSLAGV LLLVIVQSQL ASPLQEAEDN SSLETADSLL EDLRGVPNMK RQSEGTFSNY
YSKYQEERMA RDFLHWLMNS KRSGAPSKRH ADGTYTSDVS TYLQDQAAKD FVSWLKSGPA
RRESAEESMN GPMSRRHVDG SFTSDVNKVL DSLAAKEYLL WVMTSKTSGK SNKRQEDH
