ID   GLUC2_PETMA             Reviewed;         120 AA.
AC   Q9PUR0;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Glucagon-2;
DE   Contains:
DE     RecName: Full=Glucagon-2;
DE     AltName: Full=Glucagon II;
DE              Short=Glu II;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 2-II;
DE              Short=GLP-2II;
DE   Flags: Precursor;
GN   Name=gcg2;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=10555286; DOI=10.1093/oxfordjournals.molbev.a026067;
RA   Irwin D.M., Huner O., Youson J.H.;
RT   "Lamprey proglucagon and the origin of glucagon-like peptides.";
RL   Mol. Biol. Evol. 16:1548-1557(1999).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; AF159708; AAF09187.1; -; mRNA.
DR   AlphaFoldDB; Q9PUR0; -.
DR   SMR; Q9PUR0; -.
DR   STRING; 7757.ENSPMAP00000006569; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 2.
DR   Pfam; PF00123; Hormone_2; 2.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000305"
FT   PROPEP          ?..42
FT                   /id="PRO_0000011377"
FT   PEPTIDE         44..72
FT                   /note="Glucagon-2"
FT                   /id="PRO_0000011378"
FT   PROPEP          75..86
FT                   /id="PRO_0000011379"
FT   PEPTIDE         89..120
FT                   /note="Glucagon-like peptide 2-II"
FT                   /id="PRO_0000011380"
SQ   SEQUENCE   120 AA;  13397 MW;  FBDE667B96E198D8 CRC64;
     MSNASGTLLS YMFMMLLGLT LASLVPHETD DGDLNAEISL ANRHSQGSFT SDYSKHLDVK
     QAKDFVTWLL NTKRRGVDAQ AGANLEKRHS DGSFTNDMNV MLDRMSAKNF LEWLKQQGRG