ID   GLUC4_HUSDA             Reviewed;          31 AA.
AC   C0HJJ2;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Glucagon-4;
DE   AltName: Full=Glucagon-IV {ECO:0000303|PubMed:11150638};
OS   Huso dauricus (Kaluga sturgeon) (Acipenser dauricus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Huso.
OX   NCBI_TaxID=55293;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas {ECO:0000269|PubMed:11150638};
RX   PubMed=11150638; DOI=10.1016/s0196-9781(00)00337-5;
RA   Andoh T., Nagasawa H., Matsubara T.;
RT   "Multiple molecular forms of glucagon and insulin in the kaluga sturgeon,
RT   Huso dauricus.";
RL   Peptides 21:1785-1792(2000).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000255}.
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DR   AlphaFoldDB; C0HJJ2; -.
DR   SMR; C0HJJ2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Glucagon-4"
FT                   /evidence="ECO:0000269|PubMed:11150638"
FT                   /id="PRO_0000429402"
SQ   SEQUENCE   31 AA;  3682 MW;  E4E734DDFA720653 CRC64;
     HSQGMFTNDY SKYLEEKSAK EFVEWLKNGK S